Thiadiazine Derivatives as Antiprotozoal New Drugs

The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature...

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Detalles Bibliográficos
Autores principales: Bermello, Julieta Coro, Piñeiro, Rolando Pérez, Fidalgo, Lianet Monzote, Cabrera, Hortensia Rodríguez, Navarro, Margarita Suárez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111732/
https://www.ncbi.nlm.nih.gov/pubmed/21673837
http://dx.doi.org/10.2174/1874104501105010051
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author Bermello, Julieta Coro
Piñeiro, Rolando Pérez
Fidalgo, Lianet Monzote
Cabrera, Hortensia Rodríguez
Navarro, Margarita Suárez
author_facet Bermello, Julieta Coro
Piñeiro, Rolando Pérez
Fidalgo, Lianet Monzote
Cabrera, Hortensia Rodríguez
Navarro, Margarita Suárez
author_sort Bermello, Julieta Coro
collection PubMed
description The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed.
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spelling pubmed-31117322011-06-13 Thiadiazine Derivatives as Antiprotozoal New Drugs Bermello, Julieta Coro Piñeiro, Rolando Pérez Fidalgo, Lianet Monzote Cabrera, Hortensia Rodríguez Navarro, Margarita Suárez Open Med Chem J Article The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities. How the chemical nature of N-substituents influences the overall activity / cytotoxicity profile will also be discussed. Bentham Open 2011-03-09 /pmc/articles/PMC3111732/ /pubmed/21673837 http://dx.doi.org/10.2174/1874104501105010051 Text en © Bermello et al.; Licensee Bentham Open. http: //creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Bermello, Julieta Coro
Piñeiro, Rolando Pérez
Fidalgo, Lianet Monzote
Cabrera, Hortensia Rodríguez
Navarro, Margarita Suárez
Thiadiazine Derivatives as Antiprotozoal New Drugs
title Thiadiazine Derivatives as Antiprotozoal New Drugs
title_full Thiadiazine Derivatives as Antiprotozoal New Drugs
title_fullStr Thiadiazine Derivatives as Antiprotozoal New Drugs
title_full_unstemmed Thiadiazine Derivatives as Antiprotozoal New Drugs
title_short Thiadiazine Derivatives as Antiprotozoal New Drugs
title_sort thiadiazine derivatives as antiprotozoal new drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111732/
https://www.ncbi.nlm.nih.gov/pubmed/21673837
http://dx.doi.org/10.2174/1874104501105010051
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