Cargando…
Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study
BACKGROUND: Several studies have shown that variants in the glucokinase regulatory protein gene (GCKR) were associated with type 2 diabetes and dyslipidemia. The purpose of this study was to examine whether tag single nucleotide polymorphisms (SNPs) in the GCKR region were associated with type 2 dia...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112072/ https://www.ncbi.nlm.nih.gov/pubmed/21569451 http://dx.doi.org/10.1186/1471-2350-12-66 |
_version_ | 1782205691200536576 |
---|---|
author | Ling, Yan Li, Xiaomu Gu, Qian Chen, Hongyan Lu, Daru Gao, Xin |
author_facet | Ling, Yan Li, Xiaomu Gu, Qian Chen, Hongyan Lu, Daru Gao, Xin |
author_sort | Ling, Yan |
collection | PubMed |
description | BACKGROUND: Several studies have shown that variants in the glucokinase regulatory protein gene (GCKR) were associated with type 2 diabetes and dyslipidemia. The purpose of this study was to examine whether tag single nucleotide polymorphisms (SNPs) in the GCKR region were associated with type 2 diabetes and related traits in a Han Chinese population and to identify the potential mechanisms underlying these associations. METHODS: We investigated the association of polymorphisms in the GCKR gene with type 2 diabetes by employing a case-control study design (1118 cases and 1161 controls). Four tag SNPs (rs8179206, rs2293572, rs3817588 and rs780094) with pairwise r(2 )> 0.8 and minor allele frequency > 0.05 across the GCKR gene and its flanking regions were studied and haplotypes were constructed. Genotyping was performed by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy using a MassARRAY platform. RESULTS: The G alleles of GCKR rs3817588 and rs780094 were associated with an increased risk of type 2 diabetes after adjustment for year of birth, sex and BMI (OR = 1.24, 95% CI 1.08-1.43, p = 0.002 and OR = 1.22, 95% CI 1.07-1.38, p = 0.002, respectively). In the non-diabetic controls, the GG carriers of rs3817588 and rs780094 were nominally associated with a lower plasma triglyceride level compared to the AA carriers after adjustment for year of birth, sex and BMI (p for trend = 0.00004 and 0.03, respectively). Furthermore, the association of rs3817588 with plasma triglyceride level was still significant after correcting for multiple testing. CONCLUSIONS: The rs3817588 A/G polymorphism of the GCKR gene was associated with type 2 diabetes and plasma triglyceride level in the Han Chinese population. |
format | Online Article Text |
id | pubmed-3112072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31120722011-06-11 Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study Ling, Yan Li, Xiaomu Gu, Qian Chen, Hongyan Lu, Daru Gao, Xin BMC Med Genet Research Article BACKGROUND: Several studies have shown that variants in the glucokinase regulatory protein gene (GCKR) were associated with type 2 diabetes and dyslipidemia. The purpose of this study was to examine whether tag single nucleotide polymorphisms (SNPs) in the GCKR region were associated with type 2 diabetes and related traits in a Han Chinese population and to identify the potential mechanisms underlying these associations. METHODS: We investigated the association of polymorphisms in the GCKR gene with type 2 diabetes by employing a case-control study design (1118 cases and 1161 controls). Four tag SNPs (rs8179206, rs2293572, rs3817588 and rs780094) with pairwise r(2 )> 0.8 and minor allele frequency > 0.05 across the GCKR gene and its flanking regions were studied and haplotypes were constructed. Genotyping was performed by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy using a MassARRAY platform. RESULTS: The G alleles of GCKR rs3817588 and rs780094 were associated with an increased risk of type 2 diabetes after adjustment for year of birth, sex and BMI (OR = 1.24, 95% CI 1.08-1.43, p = 0.002 and OR = 1.22, 95% CI 1.07-1.38, p = 0.002, respectively). In the non-diabetic controls, the GG carriers of rs3817588 and rs780094 were nominally associated with a lower plasma triglyceride level compared to the AA carriers after adjustment for year of birth, sex and BMI (p for trend = 0.00004 and 0.03, respectively). Furthermore, the association of rs3817588 with plasma triglyceride level was still significant after correcting for multiple testing. CONCLUSIONS: The rs3817588 A/G polymorphism of the GCKR gene was associated with type 2 diabetes and plasma triglyceride level in the Han Chinese population. BioMed Central 2011-05-13 /pmc/articles/PMC3112072/ /pubmed/21569451 http://dx.doi.org/10.1186/1471-2350-12-66 Text en Copyright ©2011 Ling et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ling, Yan Li, Xiaomu Gu, Qian Chen, Hongyan Lu, Daru Gao, Xin Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
title | Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
title_full | Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
title_fullStr | Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
title_full_unstemmed | Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
title_short | Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study |
title_sort | associations of common polymorphisms in gckr with type 2 diabetes and related traits in a han chinese population: a case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112072/ https://www.ncbi.nlm.nih.gov/pubmed/21569451 http://dx.doi.org/10.1186/1471-2350-12-66 |
work_keys_str_mv | AT lingyan associationsofcommonpolymorphismsingckrwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT lixiaomu associationsofcommonpolymorphismsingckrwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT guqian associationsofcommonpolymorphismsingckrwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT chenhongyan associationsofcommonpolymorphismsingckrwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT ludaru associationsofcommonpolymorphismsingckrwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy AT gaoxin associationsofcommonpolymorphismsingckrwithtype2diabetesandrelatedtraitsinahanchinesepopulationacasecontrolstudy |