Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

BACKGROUND: Celastrol is an active ingredient of the traditional Chinese medicinal plant Tripterygium Wilfordii, which exhibits significant antitumor activity in different cancer models in vitro and in vivo; however, the lack of information on the target and mechanism of action of this compound have...

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Detalles Bibliográficos
Autores principales: Chen, Guozhu, Zhang, Xuhui, Zhao, Ming, Wang, Yan, Cheng, Xiang, Wang, Di, Xu, Yuanji, Du, Zhiyan, Yu, Xiaodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112161/
https://www.ncbi.nlm.nih.gov/pubmed/21569548
http://dx.doi.org/10.1186/1471-2407-11-170

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