Cargando…
Protective Effects of Positive Lysosomal Modulation in Alzheimer's Disease Transgenic Mouse Models
Alzheimer's disease (AD) is an age-related neurodegenerative pathology in which defects in proteolytic clearance of amyloid β peptide (Aβ) likely contribute to the progressive nature of the disorder. Lysosomal proteases of the cathepsin family exhibit up-regulation in response to accumulating p...
Autores principales: | Butler, David, Hwang, Jeannie, Estick, Candice, Nishiyama, Akiko, Kumar, Saranya Santhosh, Baveghems, Clive, Young-Oxendine, Hollie B., Wisniewski, Meagan L., Charalambides, Ana, Bahr, Ben A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112200/ https://www.ncbi.nlm.nih.gov/pubmed/21695208 http://dx.doi.org/10.1371/journal.pone.0020501 |
Ejemplares similares
-
The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer’s Disease and Parkinson’s Disease and Models of Mild Cognitive Impairment
por: Hwang, Jeannie, et al.
Publicado: (2019) -
Impairments in Neurogenesis Are Not Tightly Linked to Depressive Behavior in a Transgenic Mouse Model of Alzheimer's Disease
por: Iascone, Daniel M., et al.
Publicado: (2013) -
TRANSGENIC MOUSE MODELS OF ALZHEIMER’S DISEASE
por: Henry-Smith, Charnae A, et al.
Publicado: (2019) -
Autophagic/lysosomal dysfunction in Alzheimer’s disease
por: Orr, Miranda E, et al.
Publicado: (2013) -
High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation
por: Wang, Min, et al.
Publicado: (2021)