Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells

Histone deacetylase inhibitors (HDACi) are promising anti-cancer agents, however, their mechanisms of action remain unclear. In acute myeloid leukemia (AML) cells, HDACi have been reported to arrest growth and induce apoptosis. In this study, we elucidate details of the DNA damage induced by the HDA...

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Detalles Bibliográficos
Autores principales: Petruccelli, Luca A., Dupéré-Richer, Daphné, Pettersson, Filippa, Retrouvey, Hélène, Skoulikas, Sophia, Miller, Wilson H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112218/
https://www.ncbi.nlm.nih.gov/pubmed/21695163
http://dx.doi.org/10.1371/journal.pone.0020987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112218/
https://www.ncbi.nlm.nih.gov/pubmed/21695163
http://dx.doi.org/10.1371/journal.pone.0020987

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