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The impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations

OBJECTIVE: To investigate the effect of advanced maternal age (AMA) separately in nulliparous and multiparous women on obstetric and perinatal outcomes in singleton gestations. STUDY DESIGN: A historical cohort study on data from 6,619 singleton pregnancies between 2004 and May 2007 was performed. A...

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Autores principales: Wang, Yun, Tanbo, Tom, Åbyholm, Thomas, Henriksen, Tore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112324/
https://www.ncbi.nlm.nih.gov/pubmed/20632182
http://dx.doi.org/10.1007/s00404-010-1587-x
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author Wang, Yun
Tanbo, Tom
Åbyholm, Thomas
Henriksen, Tore
author_facet Wang, Yun
Tanbo, Tom
Åbyholm, Thomas
Henriksen, Tore
author_sort Wang, Yun
collection PubMed
description OBJECTIVE: To investigate the effect of advanced maternal age (AMA) separately in nulliparous and multiparous women on obstetric and perinatal outcomes in singleton gestations. STUDY DESIGN: A historical cohort study on data from 6,619 singleton pregnancies between 2004 and May 2007 was performed. AMA was defined as 35 years and older. Obstetric and perinatal outcomes in AMA versus women younger than 35 years (non-AMA) were compared for both nulli- and multiparae with Student’s t-test and Chi-square test in univariate analysis. Multiple logistic regression analysis was performed to examine the independent effect of AMA. RESULTS: Out of 6,619 singleton pregnancies, the frequency of nulliparity was 42.7 and 33.4% of the parturients were of AMA. Among nulliparous women, AMA was significantly associated with a higher frequency of caesarean section both before labour (OR 2.26 with 95% CI 1.74–2.94), in labour (OR 1.44 with 95% CI 1.07–1.93), and more instrumental vaginal deliveries (ORs 1.49 with 95% CI 1.13–1.96). Among multiparous women, AMA was only significantly associated with a higher caesarean section rate before labour (ORs 1.42, 95% CI 1.19–1.69). There were no significant differences between the two age groups in the prevalence of other adverse obstetric outcomes and adverse perinatal outcomes. CONCLUSIONS: Operative delivery is increased in AMA, including caesarean sections, as well as instrumental vaginal deliveries in nulliparous women. In multiparous women, however, only the rate of caesarean section before labour was increased. AMA had no significant effect on other adverse obstetric and perinatal outcomes irrespective of parity.
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spelling pubmed-31123242011-07-14 The impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations Wang, Yun Tanbo, Tom Åbyholm, Thomas Henriksen, Tore Arch Gynecol Obstet Materno-fetal Medicine OBJECTIVE: To investigate the effect of advanced maternal age (AMA) separately in nulliparous and multiparous women on obstetric and perinatal outcomes in singleton gestations. STUDY DESIGN: A historical cohort study on data from 6,619 singleton pregnancies between 2004 and May 2007 was performed. AMA was defined as 35 years and older. Obstetric and perinatal outcomes in AMA versus women younger than 35 years (non-AMA) were compared for both nulli- and multiparae with Student’s t-test and Chi-square test in univariate analysis. Multiple logistic regression analysis was performed to examine the independent effect of AMA. RESULTS: Out of 6,619 singleton pregnancies, the frequency of nulliparity was 42.7 and 33.4% of the parturients were of AMA. Among nulliparous women, AMA was significantly associated with a higher frequency of caesarean section both before labour (OR 2.26 with 95% CI 1.74–2.94), in labour (OR 1.44 with 95% CI 1.07–1.93), and more instrumental vaginal deliveries (ORs 1.49 with 95% CI 1.13–1.96). Among multiparous women, AMA was only significantly associated with a higher caesarean section rate before labour (ORs 1.42, 95% CI 1.19–1.69). There were no significant differences between the two age groups in the prevalence of other adverse obstetric outcomes and adverse perinatal outcomes. CONCLUSIONS: Operative delivery is increased in AMA, including caesarean sections, as well as instrumental vaginal deliveries in nulliparous women. In multiparous women, however, only the rate of caesarean section before labour was increased. AMA had no significant effect on other adverse obstetric and perinatal outcomes irrespective of parity. Springer-Verlag 2010-07-15 2011 /pmc/articles/PMC3112324/ /pubmed/20632182 http://dx.doi.org/10.1007/s00404-010-1587-x Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Materno-fetal Medicine
Wang, Yun
Tanbo, Tom
Åbyholm, Thomas
Henriksen, Tore
The impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations
title The impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations
title_full The impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations
title_fullStr The impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations
title_full_unstemmed The impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations
title_short The impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations
title_sort impact of advanced maternal age and parity on obstetric and perinatal outcomes in singleton gestations
topic Materno-fetal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112324/
https://www.ncbi.nlm.nih.gov/pubmed/20632182
http://dx.doi.org/10.1007/s00404-010-1587-x
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