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Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer

BACKGROUND: The association between vitamin D deficiency and obesity in healthy populations and different disease states remains unsettled with studies reporting conflicting findings. Moreover, current dietary recommendations for vitamin D do not take into account a person's body mass index (BM...

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Autores principales: Vashi, Pankaj G, Lammersfeld, Carolyn A, Braun, Donald P, Gupta, Digant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112404/
https://www.ncbi.nlm.nih.gov/pubmed/21575232
http://dx.doi.org/10.1186/1475-2891-10-51
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author Vashi, Pankaj G
Lammersfeld, Carolyn A
Braun, Donald P
Gupta, Digant
author_facet Vashi, Pankaj G
Lammersfeld, Carolyn A
Braun, Donald P
Gupta, Digant
author_sort Vashi, Pankaj G
collection PubMed
description BACKGROUND: The association between vitamin D deficiency and obesity in healthy populations and different disease states remains unsettled with studies reporting conflicting findings. Moreover, current dietary recommendations for vitamin D do not take into account a person's body mass index (BMI). We investigated the relationship between serum 25-hydroxy-vitamin D [25(OH)D] and BMI in cancer. METHODS: A consecutive case series of 738 cancer patients. Serum 25(OH)D was measured at presentation to the hospital. The cohort was divided into 4 BMI groups (underweight: <18.5, normal weight: 18.5-24.9, overweight: 25-29.9, and obese: >30.0 kg/m(2)). Mean 25(OH)D was compared across the 4 BMI groups using ANOVA. Linear regression was used to quantify the relationship between BMI and 25(OH)D. RESULTS: 303 were males and 435 females. Mean age at diagnosis was 55.6 years. The mean BMI was 27.9 kg/m(2 )and mean serum 25(OH)D was 21.9 ng/ml. Most common cancers were lung (134), breast (131), colorectal (97), pancreas (86) and prostate (45). Obese patients had significantly lower serum 25(OH)D levels (17.9 ng/ml) as compared to normal weight (24.6 ng/ml) and overweight (22.8 ng/ml) patients; p < 0.001. After adjusting for age, every 1 kg/m(2 )increase in BMI was significantly associated with 0.42 ng/ml decline in serum 25(OH)D levels. CONCLUSIONS: Obese cancer patients (BMI >= 30 kg/m(2)) had significantly lower levels of serum 25(OH)D as compared to non-obese patients (BMI <30 kg/m(2)). BMI should be taken into account when assessing a patient's vitamin D status and more aggressive vitamin D supplementation should be considered in obese cancer patients.
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spelling pubmed-31124042011-06-12 Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer Vashi, Pankaj G Lammersfeld, Carolyn A Braun, Donald P Gupta, Digant Nutr J Research BACKGROUND: The association between vitamin D deficiency and obesity in healthy populations and different disease states remains unsettled with studies reporting conflicting findings. Moreover, current dietary recommendations for vitamin D do not take into account a person's body mass index (BMI). We investigated the relationship between serum 25-hydroxy-vitamin D [25(OH)D] and BMI in cancer. METHODS: A consecutive case series of 738 cancer patients. Serum 25(OH)D was measured at presentation to the hospital. The cohort was divided into 4 BMI groups (underweight: <18.5, normal weight: 18.5-24.9, overweight: 25-29.9, and obese: >30.0 kg/m(2)). Mean 25(OH)D was compared across the 4 BMI groups using ANOVA. Linear regression was used to quantify the relationship between BMI and 25(OH)D. RESULTS: 303 were males and 435 females. Mean age at diagnosis was 55.6 years. The mean BMI was 27.9 kg/m(2 )and mean serum 25(OH)D was 21.9 ng/ml. Most common cancers were lung (134), breast (131), colorectal (97), pancreas (86) and prostate (45). Obese patients had significantly lower serum 25(OH)D levels (17.9 ng/ml) as compared to normal weight (24.6 ng/ml) and overweight (22.8 ng/ml) patients; p < 0.001. After adjusting for age, every 1 kg/m(2 )increase in BMI was significantly associated with 0.42 ng/ml decline in serum 25(OH)D levels. CONCLUSIONS: Obese cancer patients (BMI >= 30 kg/m(2)) had significantly lower levels of serum 25(OH)D as compared to non-obese patients (BMI <30 kg/m(2)). BMI should be taken into account when assessing a patient's vitamin D status and more aggressive vitamin D supplementation should be considered in obese cancer patients. BioMed Central 2011-05-16 /pmc/articles/PMC3112404/ /pubmed/21575232 http://dx.doi.org/10.1186/1475-2891-10-51 Text en Copyright ©2011 Vashi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Vashi, Pankaj G
Lammersfeld, Carolyn A
Braun, Donald P
Gupta, Digant
Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer
title Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer
title_full Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer
title_fullStr Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer
title_full_unstemmed Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer
title_short Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer
title_sort serum 25-hydroxyvitamin d is inversely associated with body mass index in cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112404/
https://www.ncbi.nlm.nih.gov/pubmed/21575232
http://dx.doi.org/10.1186/1475-2891-10-51
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