Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirme...

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Detalles Bibliográficos
Autores principales: Rijken, Marcus J, Boel, Machteld E, Russell, Bruce, Imwong, Mallika, Leimanis, Mara L, Phyo, Aung Pyae, Muehlenbachs, Atis, Lindegardh, Niklas, McGready, Rose, Rénia, Laurent, Snounou, Georges, Singhasivanon, Pratap, Nosten, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112451/
https://www.ncbi.nlm.nih.gov/pubmed/21545737
http://dx.doi.org/10.1186/1475-2875-10-113
Descripción
Sumario:Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.

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