Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirme...

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Autores principales: Rijken, Marcus J, Boel, Machteld E, Russell, Bruce, Imwong, Mallika, Leimanis, Mara L, Phyo, Aung Pyae, Muehlenbachs, Atis, Lindegardh, Niklas, McGready, Rose, Rénia, Laurent, Snounou, Georges, Singhasivanon, Pratap, Nosten, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112451/
https://www.ncbi.nlm.nih.gov/pubmed/21545737
http://dx.doi.org/10.1186/1475-2875-10-113
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author Rijken, Marcus J
Boel, Machteld E
Russell, Bruce
Imwong, Mallika
Leimanis, Mara L
Phyo, Aung Pyae
Muehlenbachs, Atis
Lindegardh, Niklas
McGready, Rose
Rénia, Laurent
Snounou, Georges
Singhasivanon, Pratap
Nosten, François
author_facet Rijken, Marcus J
Boel, Machteld E
Russell, Bruce
Imwong, Mallika
Leimanis, Mara L
Phyo, Aung Pyae
Muehlenbachs, Atis
Lindegardh, Niklas
McGready, Rose
Rénia, Laurent
Snounou, Georges
Singhasivanon, Pratap
Nosten, François
author_sort Rijken, Marcus J
collection PubMed
description Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.
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spelling pubmed-31124512011-06-12 Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand Rijken, Marcus J Boel, Machteld E Russell, Bruce Imwong, Mallika Leimanis, Mara L Phyo, Aung Pyae Muehlenbachs, Atis Lindegardh, Niklas McGready, Rose Rénia, Laurent Snounou, Georges Singhasivanon, Pratap Nosten, François Malar J Case Report Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand. BioMed Central 2011-05-05 /pmc/articles/PMC3112451/ /pubmed/21545737 http://dx.doi.org/10.1186/1475-2875-10-113 Text en Copyright ©2011 Rijken et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rijken, Marcus J
Boel, Machteld E
Russell, Bruce
Imwong, Mallika
Leimanis, Mara L
Phyo, Aung Pyae
Muehlenbachs, Atis
Lindegardh, Niklas
McGready, Rose
Rénia, Laurent
Snounou, Georges
Singhasivanon, Pratap
Nosten, François
Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
title Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
title_full Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
title_fullStr Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
title_full_unstemmed Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
title_short Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
title_sort chloroquine resistant vivax malaria in a pregnant woman on the western border of thailand
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112451/
https://www.ncbi.nlm.nih.gov/pubmed/21545737
http://dx.doi.org/10.1186/1475-2875-10-113
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