Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)

The complete genome sequences of two isolates A/chicken/Egypt/CL6/07 (CL6/07) and A/duck/Egypt/D2br10/07 (D2br10/07) of highly pathogenic avian influenza virus (HPAI) H5N1 isolated at the beginning of 2007 outbreak in Egypt were determined and compared with all Egyptian HPAI H5N1 sequences available...

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Autores principales: Ibrahim, Madiha Salah, Watanabe, Yohei, Ellakany, H. F., Yamagishi, Aki, Sapsutthipas, Sompong, Toyoda, Tetsuya, Abd El-Hamied, H. S., Ikuta, Kazuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112484/
https://www.ncbi.nlm.nih.gov/pubmed/21327896
http://dx.doi.org/10.1007/s11262-011-0583-y
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author Ibrahim, Madiha Salah
Watanabe, Yohei
Ellakany, H. F.
Yamagishi, Aki
Sapsutthipas, Sompong
Toyoda, Tetsuya
Abd El-Hamied, H. S.
Ikuta, Kazuyoshi
author_facet Ibrahim, Madiha Salah
Watanabe, Yohei
Ellakany, H. F.
Yamagishi, Aki
Sapsutthipas, Sompong
Toyoda, Tetsuya
Abd El-Hamied, H. S.
Ikuta, Kazuyoshi
author_sort Ibrahim, Madiha Salah
collection PubMed
description The complete genome sequences of two isolates A/chicken/Egypt/CL6/07 (CL6/07) and A/duck/Egypt/D2br10/07 (D2br10/07) of highly pathogenic avian influenza virus (HPAI) H5N1 isolated at the beginning of 2007 outbreak in Egypt were determined and compared with all Egyptian HPAI H5N1 sequences available in the GenBank. Sequence analysis utilizing the RNA from the original tissue homogenate showed amino acid substitutions in seven of the viral segments in both samples. Interestingly, these changes were different between the CL6/07 and D2br10/07 when compared to other Egyptian isolates. Moreover, phylogenetic analysis showed independent sub-clustering of the two viruses within the Egyptian sequences signifying a possible differential adaptation in the two hosts. Further, pre-amplification analysis of H5N1 might be necessary for accurate data interpretation and identification of distinct factor(s) influencing the evolution of the virus in different poultry species.
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spelling pubmed-31124842011-07-14 Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1) Ibrahim, Madiha Salah Watanabe, Yohei Ellakany, H. F. Yamagishi, Aki Sapsutthipas, Sompong Toyoda, Tetsuya Abd El-Hamied, H. S. Ikuta, Kazuyoshi Virus Genes Article The complete genome sequences of two isolates A/chicken/Egypt/CL6/07 (CL6/07) and A/duck/Egypt/D2br10/07 (D2br10/07) of highly pathogenic avian influenza virus (HPAI) H5N1 isolated at the beginning of 2007 outbreak in Egypt were determined and compared with all Egyptian HPAI H5N1 sequences available in the GenBank. Sequence analysis utilizing the RNA from the original tissue homogenate showed amino acid substitutions in seven of the viral segments in both samples. Interestingly, these changes were different between the CL6/07 and D2br10/07 when compared to other Egyptian isolates. Moreover, phylogenetic analysis showed independent sub-clustering of the two viruses within the Egyptian sequences signifying a possible differential adaptation in the two hosts. Further, pre-amplification analysis of H5N1 might be necessary for accurate data interpretation and identification of distinct factor(s) influencing the evolution of the virus in different poultry species. Springer US 2011-02-17 2011 /pmc/articles/PMC3112484/ /pubmed/21327896 http://dx.doi.org/10.1007/s11262-011-0583-y Text en © The Author(s) 2011 Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Ibrahim, Madiha Salah
Watanabe, Yohei
Ellakany, H. F.
Yamagishi, Aki
Sapsutthipas, Sompong
Toyoda, Tetsuya
Abd El-Hamied, H. S.
Ikuta, Kazuyoshi
Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)
title Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)
title_full Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)
title_fullStr Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)
title_full_unstemmed Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)
title_short Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)
title_sort host-specific genetic variation of highly pathogenic avian influenza viruses (h5n1)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112484/
https://www.ncbi.nlm.nih.gov/pubmed/21327896
http://dx.doi.org/10.1007/s11262-011-0583-y
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