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Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease
The accuracy of the (13)C-methacetin breath test ((13)C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the (13)C-MBT in various stages of chronic liver diseases. Diagnostic accur...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112525/ https://www.ncbi.nlm.nih.gov/pubmed/21687605 http://dx.doi.org/10.1155/2011/235796 |
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author | Razlan, Hamizah Marzuki, Nurhayaty Muhamad Tai, Mei-Ling Sharon Shamsul, Azhar-Shah Ong, Tze-Zen Mahadeva, Sanjiv |
author_facet | Razlan, Hamizah Marzuki, Nurhayaty Muhamad Tai, Mei-Ling Sharon Shamsul, Azhar-Shah Ong, Tze-Zen Mahadeva, Sanjiv |
author_sort | Razlan, Hamizah |
collection | PubMed |
description | The accuracy of the (13)C-methacetin breath test ((13)C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the (13)C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age 50 ± 16 years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The (13)C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis. |
format | Online Article Text |
id | pubmed-3112525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31125252011-06-17 Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease Razlan, Hamizah Marzuki, Nurhayaty Muhamad Tai, Mei-Ling Sharon Shamsul, Azhar-Shah Ong, Tze-Zen Mahadeva, Sanjiv Gastroenterol Res Pract Research Article The accuracy of the (13)C-methacetin breath test ((13)C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the (13)C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age 50 ± 16 years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The (13)C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis. Hindawi Publishing Corporation 2011 2011-06-07 /pmc/articles/PMC3112525/ /pubmed/21687605 http://dx.doi.org/10.1155/2011/235796 Text en Copyright © 2011 Hamizah Razlan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Razlan, Hamizah Marzuki, Nurhayaty Muhamad Tai, Mei-Ling Sharon Shamsul, Azhar-Shah Ong, Tze-Zen Mahadeva, Sanjiv Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
title | Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
title_full | Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
title_fullStr | Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
title_full_unstemmed | Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
title_short | Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease |
title_sort | diagnostic value of the (13)c methacetin breath test in various stages of chronic liver disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112525/ https://www.ncbi.nlm.nih.gov/pubmed/21687605 http://dx.doi.org/10.1155/2011/235796 |
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