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Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease

The accuracy of the (13)C-methacetin breath test ((13)C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the (13)C-MBT in various stages of chronic liver diseases. Diagnostic accur...

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Autores principales: Razlan, Hamizah, Marzuki, Nurhayaty Muhamad, Tai, Mei-Ling Sharon, Shamsul, Azhar-Shah, Ong, Tze-Zen, Mahadeva, Sanjiv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112525/
https://www.ncbi.nlm.nih.gov/pubmed/21687605
http://dx.doi.org/10.1155/2011/235796
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author Razlan, Hamizah
Marzuki, Nurhayaty Muhamad
Tai, Mei-Ling Sharon
Shamsul, Azhar-Shah
Ong, Tze-Zen
Mahadeva, Sanjiv
author_facet Razlan, Hamizah
Marzuki, Nurhayaty Muhamad
Tai, Mei-Ling Sharon
Shamsul, Azhar-Shah
Ong, Tze-Zen
Mahadeva, Sanjiv
author_sort Razlan, Hamizah
collection PubMed
description The accuracy of the (13)C-methacetin breath test ((13)C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the (13)C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age 50 ± 16 years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The (13)C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis.
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spelling pubmed-31125252011-06-17 Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease Razlan, Hamizah Marzuki, Nurhayaty Muhamad Tai, Mei-Ling Sharon Shamsul, Azhar-Shah Ong, Tze-Zen Mahadeva, Sanjiv Gastroenterol Res Pract Research Article The accuracy of the (13)C-methacetin breath test ((13)C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the (13)C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age 50 ± 16 years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99). The (13)C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis. Hindawi Publishing Corporation 2011 2011-06-07 /pmc/articles/PMC3112525/ /pubmed/21687605 http://dx.doi.org/10.1155/2011/235796 Text en Copyright © 2011 Hamizah Razlan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Razlan, Hamizah
Marzuki, Nurhayaty Muhamad
Tai, Mei-Ling Sharon
Shamsul, Azhar-Shah
Ong, Tze-Zen
Mahadeva, Sanjiv
Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease
title Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease
title_full Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease
title_fullStr Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease
title_full_unstemmed Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease
title_short Diagnostic Value of the (13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease
title_sort diagnostic value of the (13)c methacetin breath test in various stages of chronic liver disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112525/
https://www.ncbi.nlm.nih.gov/pubmed/21687605
http://dx.doi.org/10.1155/2011/235796
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