Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182

Enantioselective reductions of p-R(1)-C(6)H(4)C(O)CH(2)R(2) (R(1) = Cl, Br, CH(3), OCH(3), NO(2) and R(2) = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent...

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Autores principales: Fardelone, Lucídio C., Rodrigues, J. Augusto R., Moran, Paulo J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113109/
https://www.ncbi.nlm.nih.gov/pubmed/21687613
http://dx.doi.org/10.4061/2011/976368
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author Fardelone, Lucídio C.
Rodrigues, J. Augusto R.
Moran, Paulo J. S.
author_facet Fardelone, Lucídio C.
Rodrigues, J. Augusto R.
Moran, Paulo J. S.
author_sort Fardelone, Lucídio C.
collection PubMed
description Enantioselective reductions of p-R(1)-C(6)H(4)C(O)CH(2)R(2) (R(1) = Cl, Br, CH(3), OCH(3), NO(2) and R(2) = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries.
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spelling pubmed-31131092011-06-17 Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 Fardelone, Lucídio C. Rodrigues, J. Augusto R. Moran, Paulo J. S. Enzyme Res Research Article Enantioselective reductions of p-R(1)-C(6)H(4)C(O)CH(2)R(2) (R(1) = Cl, Br, CH(3), OCH(3), NO(2) and R(2) = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries. SAGE-Hindawi Access to Research 2011-06-02 /pmc/articles/PMC3113109/ /pubmed/21687613 http://dx.doi.org/10.4061/2011/976368 Text en Copyright © 2011 Lucídio C. Fardelone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fardelone, Lucídio C.
Rodrigues, J. Augusto R.
Moran, Paulo J. S.
Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182
title Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182
title_full Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182
title_fullStr Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182
title_full_unstemmed Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182
title_short Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182
title_sort chiral pharmaceutical intermediaries obtained by reduction of 2-halo-1-(4-substituted phenyl)-ethanones mediated by geotrichum candidum cct 1205 and rhodotorula glutinis cct 2182
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113109/
https://www.ncbi.nlm.nih.gov/pubmed/21687613
http://dx.doi.org/10.4061/2011/976368
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