Cargando…

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

Transforming growth factor β (TGFβ) is a pluripotent cytokine promoting epithelial cell plasticity during morphogenesis and tumour progression. TGFβ binding to type II and type I serine/threonine kinase receptors (TβRII and TβRI) causes activation of different intracellular signaling pathways. TβRI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mu, Yabing, Sundar, Reshma, Thakur, Noopur, Ekman, Maria, Gudey, Shyam Kumar, Yakymovych, Mariya, Hermansson, Annika, Dimitriou, Helen, Bengoechea-Alonso, Maria Teresa, Ericsson, Johan, Heldin, Carl-Henrik, Landström, Marene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113296/ https://www.ncbi.nlm.nih.gov/pubmed/21629263 http://dx.doi.org/10.1038/ncomms1332

Ejemplares similares

TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor
por: Sundar, Reshma, et al.
Publicado: (2015)

Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGFβ stimulation in cancer
por: Gudey, Shyam Kumar, et al.
Publicado: (2017)

TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1
por: Thakur, Noopur, et al.
Publicado: (2014)

CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface
por: Yakymovych, Ihor, et al.
Publicado: (2015)

The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
por: Song, Jie, et al.
Publicado: (2022)

APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration
por: Ekman, Maria, et al.
Publicado: (2012)

TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
por: Aripaka, Karthik, et al.
Publicado: (2019)

TGFβ activates PI3K-AKT signaling via TRAF6
por: Song, Jie, et al.
Publicado: (2017)

Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
por: Thakur, Noopur, et al.
Publicado: (2020)

APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain
por: Song, Jie, et al.
Publicado: (2015)

TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation
por: Kolliopoulos, Constantinos, et al.
Publicado: (2021)

PKCζ facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model
por: Zang, Guangxiang, et al.
Publicado: (2019)

The 2019 FASEB Science Research Conference on the TGF-β Superfamily: Signaling in Development and Disease, July 28 to August 2, 2019, West Palm Beach, Florida, USA
por: Landström, Marene, et al.
Publicado: (2019)

Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein
por: Davoodpour, Padideh, et al.
Publicado: (2007)

The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis
por: Mallikarjuna, Pramod, et al.
Publicado: (2022)

Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma
por: Sitaram, Raviprakash T., et al.
Publicado: (2016)

VHL status regulates transforming growth factor-β signaling pathways in renal cell carcinoma
por: Mallikarjuna, Pramod, et al.
Publicado: (2018)

Helicobacter pylori inhibits the cleavage of TRAF1 via a CagA-dependent mechanism
por: Wan, Xiu-Kun, et al.
Publicado: (2016)

Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma
por: Mallikarjuna, Pramod, et al.
Publicado: (2019)

The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth
por: Bengoechea-Alonso, Maria Teresa, et al.
Publicado: (2016)

The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis
por: Aldaalis, Arwa, et al.
Publicado: (2022)

Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis
por: Bengoechea-Alonso, Maria T., et al.
Publicado: (2022)

Cytokine Secretion, Viability, and Real-Time Proliferation of Apical-Papilla Stem Cells Upon Exposure to Oral Bacteria
por: Rakhimova, Olena, et al.
Publicado: (2021)

Comparison of Target Recognition by TRAF1 and TRAF2
por: Kim, Chang Min, et al.
Publicado: (2020)

Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes
por: Chand, Mahesh Kumar, et al.
Publicado: (2015)

Crystal structure of TRAF1 TRAF domain and its implications in the TRAF1-mediated intracellular signaling pathway
por: Kim, Chang Min, et al.
Publicado: (2016)

Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation
por: Ginster, Stefanie, et al.
Publicado: (2017)

FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior
por: Chioni, Athina-Myrto, et al.
Publicado: (2012)

TRAF2 decreases lipid accumulation in hepatocytes under endoplasmic reticulum stress: TRAF2 increases the ubiquitination of XBP1s
por: Li, Siqi, et al.
Publicado: (2023)

PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element–modifying factor 1
por: Papadopoulos, Natalia, et al.
Publicado: (2018)

Different Activation of TRAF4 and TRAF6 in Inflammatory Bowel Disease
por: Shen, Jun, et al.
Publicado: (2013)

Combined Transcriptomic and Protein Array Cytokine Profiling of Human Stem Cells from Dental Apical Papilla Modulated by Oral Bacteria
por: Zymovets, Valeriia, et al.
Publicado: (2022)

Non-autocrine, constitutive activation of Met in human anaplastic thyroid carcinoma cells in culture
por: Bergström, J D, et al.
Publicado: (1999)

Functional Coupling of Duplex Translocation to DNA Cleavage in a Type I Restriction Enzyme
por: Csefalvay, Eva, et al.
Publicado: (2015)

Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein
por: Mosbahi, Khedidja, et al.
Publicado: (2018)

TRAF1 Signaling in Human Health and Disease
por: Edilova, Maria I., et al.
Publicado: (2018)

(+)-Vitisin A Inhibits Osteoclast Differentiation by Preventing TRAF6 Ubiquitination and TRAF6-TAK1 Formation to Suppress NFATc1 Activation
por: Chiou, Wen-Fei, et al.
Publicado: (2014)

Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6
por: Chen, Hai-Wei, et al.
Publicado: (2015)

Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling
por: Arron, Joseph R., et al.
Publicado: (2002)

Up-regulation and Pre-activation of TRAF3 and TRAF5 in Inflammatory Bowel Disease
por: Shen, Jun, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_bepmrv6gljcrp0l1e87hdccquc