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Similarities and differences in structure, expression, and functions of VLDLR and ApoER2

Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members...

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Detalles Bibliográficos
Autores principales: Reddy, Sunil S, Connor, Teal E, Weeber, Edwin J, Rebeck, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113299/
https://www.ncbi.nlm.nih.gov/pubmed/21554715
http://dx.doi.org/10.1186/1750-1326-6-30
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author Reddy, Sunil S
Connor, Teal E
Weeber, Edwin J
Rebeck, William
author_facet Reddy, Sunil S
Connor, Teal E
Weeber, Edwin J
Rebeck, William
author_sort Reddy, Sunil S
collection PubMed
description Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members of the low density lipoprotein family, which also mediates the effects of numerous other extracellular ligands, including apolipoprotein E. Although VLDLR and ApoER2 are highly homologous, they differ in a number of ways, including structural differences, expression patterns, alternative splicing, and binding of extracellular and intracellular proteins. This review aims to summarize important aspects of VLDLR and ApoER2 that may account for interesting recent findings that highlight the unique functions of each receptor.
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spelling pubmed-31132992011-06-14 Similarities and differences in structure, expression, and functions of VLDLR and ApoER2 Reddy, Sunil S Connor, Teal E Weeber, Edwin J Rebeck, William Mol Neurodegener Review Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members of the low density lipoprotein family, which also mediates the effects of numerous other extracellular ligands, including apolipoprotein E. Although VLDLR and ApoER2 are highly homologous, they differ in a number of ways, including structural differences, expression patterns, alternative splicing, and binding of extracellular and intracellular proteins. This review aims to summarize important aspects of VLDLR and ApoER2 that may account for interesting recent findings that highlight the unique functions of each receptor. BioMed Central 2011-05-09 /pmc/articles/PMC3113299/ /pubmed/21554715 http://dx.doi.org/10.1186/1750-1326-6-30 Text en Copyright ©2011 Reddy et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Reddy, Sunil S
Connor, Teal E
Weeber, Edwin J
Rebeck, William
Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
title Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
title_full Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
title_fullStr Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
title_full_unstemmed Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
title_short Similarities and differences in structure, expression, and functions of VLDLR and ApoER2
title_sort similarities and differences in structure, expression, and functions of vldlr and apoer2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113299/
https://www.ncbi.nlm.nih.gov/pubmed/21554715
http://dx.doi.org/10.1186/1750-1326-6-30
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