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Thermodynamic and kinetic basis for recognition and repair of 8-oxoguanine in DNA by human 8-oxoguanine-DNA glycosylase
We have used a stepwise increase in ligand complexity approach to estimate the relative contributions of the nucleotide units of DNA containing 7,8-dihydro-8-oxoguanine (oxoG) to its total affinity for human 8-oxoguanine DNA glycosylase (OGG1) and construct thermodynamic models of the enzyme interac...
Autores principales: | Kirpota, Oleg O., Endutkin, Anton V., Ponomarenko, Michail P., Ponomarenko, Petr M., Zharkov, Dmitry O., Nevinsky, Georgy A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113562/ https://www.ncbi.nlm.nih.gov/pubmed/21343179 http://dx.doi.org/10.1093/nar/gkq1333 |
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