Cargando…

The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?

Pif1 family helicases, which are found in nearly all eukaryotes, have important roles in both nuclear and mitochondrial genome maintenance. Recently, the increasing availability of genome sequences has revealed that Pif1 helicases are also widely found in diverse prokaryotes, but it is currently unk...

Descripción completa

Detalles Bibliográficos
Autores principales: Bochman, Matthew L., Judge, Colleen P., Zakian, Virginia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113762/
https://www.ncbi.nlm.nih.gov/pubmed/21670310
http://dx.doi.org/10.1091/mbc.E11-01-0045
_version_ 1782205965710393344
author Bochman, Matthew L.
Judge, Colleen P.
Zakian, Virginia A.
author_facet Bochman, Matthew L.
Judge, Colleen P.
Zakian, Virginia A.
author_sort Bochman, Matthew L.
collection PubMed
description Pif1 family helicases, which are found in nearly all eukaryotes, have important roles in both nuclear and mitochondrial genome maintenance. Recently, the increasing availability of genome sequences has revealed that Pif1 helicases are also widely found in diverse prokaryotes, but it is currently unknown what physiological function(s) prokaryotic Pif1 helicases might perform. This Perspective aims to briefly introduce the reader to the well-studied eukaryotic Pif1 family helicases and speculate on what roles such enzymes may play in bacteria. On the basis of our hypotheses, we predict that Pif1 family helicases are important for resolving common issues that arise during DNA replication, recombination, and repair rather than functioning in a eukaryotic-specific manner.
format Online
Article
Text
id pubmed-3113762
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher The American Society for Cell Biology
record_format MEDLINE/PubMed
spelling pubmed-31137622011-08-30 The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? Bochman, Matthew L. Judge, Colleen P. Zakian, Virginia A. Mol Biol Cell Perspective Pif1 family helicases, which are found in nearly all eukaryotes, have important roles in both nuclear and mitochondrial genome maintenance. Recently, the increasing availability of genome sequences has revealed that Pif1 helicases are also widely found in diverse prokaryotes, but it is currently unknown what physiological function(s) prokaryotic Pif1 helicases might perform. This Perspective aims to briefly introduce the reader to the well-studied eukaryotic Pif1 family helicases and speculate on what roles such enzymes may play in bacteria. On the basis of our hypotheses, we predict that Pif1 family helicases are important for resolving common issues that arise during DNA replication, recombination, and repair rather than functioning in a eukaryotic-specific manner. The American Society for Cell Biology 2011-06-15 /pmc/articles/PMC3113762/ /pubmed/21670310 http://dx.doi.org/10.1091/mbc.E11-01-0045 Text en © 2011 Bochman et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
spellingShingle Perspective
Bochman, Matthew L.
Judge, Colleen P.
Zakian, Virginia A.
The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?
title The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?
title_full The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?
title_fullStr The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?
title_full_unstemmed The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?
title_short The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?
title_sort pif1 family in prokaryotes: what are our helicases doing in your bacteria?
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113762/
https://www.ncbi.nlm.nih.gov/pubmed/21670310
http://dx.doi.org/10.1091/mbc.E11-01-0045
work_keys_str_mv AT bochmanmatthewl thepif1familyinprokaryoteswhatareourhelicasesdoinginyourbacteria
AT judgecolleenp thepif1familyinprokaryoteswhatareourhelicasesdoinginyourbacteria
AT zakianvirginiaa thepif1familyinprokaryoteswhatareourhelicasesdoinginyourbacteria
AT bochmanmatthewl pif1familyinprokaryoteswhatareourhelicasesdoinginyourbacteria
AT judgecolleenp pif1familyinprokaryoteswhatareourhelicasesdoinginyourbacteria
AT zakianvirginiaa pif1familyinprokaryoteswhatareourhelicasesdoinginyourbacteria