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The Pif1 family in prokaryotes: what are our helicases doing in your bacteria?
Pif1 family helicases, which are found in nearly all eukaryotes, have important roles in both nuclear and mitochondrial genome maintenance. Recently, the increasing availability of genome sequences has revealed that Pif1 helicases are also widely found in diverse prokaryotes, but it is currently unk...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113762/ https://www.ncbi.nlm.nih.gov/pubmed/21670310 http://dx.doi.org/10.1091/mbc.E11-01-0045 |
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author | Bochman, Matthew L. Judge, Colleen P. Zakian, Virginia A. |
author_facet | Bochman, Matthew L. Judge, Colleen P. Zakian, Virginia A. |
author_sort | Bochman, Matthew L. |
collection | PubMed |
description | Pif1 family helicases, which are found in nearly all eukaryotes, have important roles in both nuclear and mitochondrial genome maintenance. Recently, the increasing availability of genome sequences has revealed that Pif1 helicases are also widely found in diverse prokaryotes, but it is currently unknown what physiological function(s) prokaryotic Pif1 helicases might perform. This Perspective aims to briefly introduce the reader to the well-studied eukaryotic Pif1 family helicases and speculate on what roles such enzymes may play in bacteria. On the basis of our hypotheses, we predict that Pif1 family helicases are important for resolving common issues that arise during DNA replication, recombination, and repair rather than functioning in a eukaryotic-specific manner. |
format | Online Article Text |
id | pubmed-3113762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-31137622011-08-30 The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? Bochman, Matthew L. Judge, Colleen P. Zakian, Virginia A. Mol Biol Cell Perspective Pif1 family helicases, which are found in nearly all eukaryotes, have important roles in both nuclear and mitochondrial genome maintenance. Recently, the increasing availability of genome sequences has revealed that Pif1 helicases are also widely found in diverse prokaryotes, but it is currently unknown what physiological function(s) prokaryotic Pif1 helicases might perform. This Perspective aims to briefly introduce the reader to the well-studied eukaryotic Pif1 family helicases and speculate on what roles such enzymes may play in bacteria. On the basis of our hypotheses, we predict that Pif1 family helicases are important for resolving common issues that arise during DNA replication, recombination, and repair rather than functioning in a eukaryotic-specific manner. The American Society for Cell Biology 2011-06-15 /pmc/articles/PMC3113762/ /pubmed/21670310 http://dx.doi.org/10.1091/mbc.E11-01-0045 Text en © 2011 Bochman et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology. |
spellingShingle | Perspective Bochman, Matthew L. Judge, Colleen P. Zakian, Virginia A. The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? |
title | The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? |
title_full | The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? |
title_fullStr | The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? |
title_full_unstemmed | The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? |
title_short | The Pif1 family in prokaryotes: what are our helicases doing in your bacteria? |
title_sort | pif1 family in prokaryotes: what are our helicases doing in your bacteria? |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113762/ https://www.ncbi.nlm.nih.gov/pubmed/21670310 http://dx.doi.org/10.1091/mbc.E11-01-0045 |
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