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A yeast model for polyalanine-expansion aggregation and toxicity

Nine human disorders result from the toxic accumulation and aggregation of proteins with expansions in their endogenous polyalanine (polyA) tracts. Given the prevalence of polyA tracts in eukaryotic proteomes, we wanted to understand the generality of polyA-expansion cytotoxicity by using yeast as a...

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Detalles Bibliográficos
Autores principales:	Konopka, Catherine A., Locke, Melissa N., Gallagher, Pamela S., Pham, Ngan, Hart, Michael P., Walker, Claire J., Gitler, Aaron D., Gardner, Richard G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113764/ https://www.ncbi.nlm.nih.gov/pubmed/21508314 http://dx.doi.org/10.1091/mbc.E11-01-0037

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