Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

BACKGROUND: Evidence indicates that Bax functions as a “lipidic” pore to regulate mitochondrial outer membrane permeabilization (MOMP), the apoptosis commitment step, through unknown membrane elements. Here we show mitochondrial ceramide elevation facilitates MOMP-mediated cytochrome c release in He...

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Detalles Bibliográficos
Autores principales: Lee, Hyunmi, Rotolo, Jimmy A., Mesicek, Judith, Penate-Medina, Tuula, Rimner, Andreas, Liao, Wen-Chieh, Yin, Xianglei, Ragupathi, Govind, Ehleiter, Desiree, Gulbins, Erich, Zhai, Dayong, Reed, John C., Haimovitz-Friedman, Adriana, Fuks, Zvi, Kolesnick, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113798/
https://www.ncbi.nlm.nih.gov/pubmed/21695182
http://dx.doi.org/10.1371/journal.pone.0019783

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