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Temperature Modulation of Electric Fields in Biological Matter
Pulsed electric fields (PEF) have become an important minimally invasive surgical technology for various applications including genetic engineering, electrochemotherapy and tissue ablation. This study explores the hypothesis that temperature dependent electrical parameters of tissue can be used to m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113852/ https://www.ncbi.nlm.nih.gov/pubmed/21695144 http://dx.doi.org/10.1371/journal.pone.0020877 |
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author | Daniels, Charlotte S. Rubinsky, Boris |
author_facet | Daniels, Charlotte S. Rubinsky, Boris |
author_sort | Daniels, Charlotte S. |
collection | PubMed |
description | Pulsed electric fields (PEF) have become an important minimally invasive surgical technology for various applications including genetic engineering, electrochemotherapy and tissue ablation. This study explores the hypothesis that temperature dependent electrical parameters of tissue can be used to modulate the outcome of PEF protocols, providing a new means for controlling and optimizing this minimally invasive surgical procedure. This study investigates two different applications of cooling temperatures applied during PEF. The first case utilizes an electrode which simultaneously delivers pulsed electric fields and cooling temperatures. The subsequent results demonstrate that changes in electrical properties due to temperature produced by this configuration can substantially magnify and confine the electric fields in the cooled regions while almost eliminating electric fields in surrounding regions. This method can be used to increase precision in the PEF procedure, and eliminate muscle contractions and damage to adjacent tissues. The second configuration considered introduces a third probe that is not electrically active and only applies cooling boundary conditions. This second study demonstrates that in this probe configuration the temperature induced changes in electrical properties of tissue substantially reduce the electric fields in the cooled regions. This novel treatment can potentially be used to protect sensitive tissues from the effect of the PEF. Perhaps the most important conclusion of this investigation is that temperature is a powerful and accessible mechanism to modulate and control electric fields in biological tissues and can therefore be used to optimize and control PEF treatments. |
format | Online Article Text |
id | pubmed-3113852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31138522011-06-21 Temperature Modulation of Electric Fields in Biological Matter Daniels, Charlotte S. Rubinsky, Boris PLoS One Research Article Pulsed electric fields (PEF) have become an important minimally invasive surgical technology for various applications including genetic engineering, electrochemotherapy and tissue ablation. This study explores the hypothesis that temperature dependent electrical parameters of tissue can be used to modulate the outcome of PEF protocols, providing a new means for controlling and optimizing this minimally invasive surgical procedure. This study investigates two different applications of cooling temperatures applied during PEF. The first case utilizes an electrode which simultaneously delivers pulsed electric fields and cooling temperatures. The subsequent results demonstrate that changes in electrical properties due to temperature produced by this configuration can substantially magnify and confine the electric fields in the cooled regions while almost eliminating electric fields in surrounding regions. This method can be used to increase precision in the PEF procedure, and eliminate muscle contractions and damage to adjacent tissues. The second configuration considered introduces a third probe that is not electrically active and only applies cooling boundary conditions. This second study demonstrates that in this probe configuration the temperature induced changes in electrical properties of tissue substantially reduce the electric fields in the cooled regions. This novel treatment can potentially be used to protect sensitive tissues from the effect of the PEF. Perhaps the most important conclusion of this investigation is that temperature is a powerful and accessible mechanism to modulate and control electric fields in biological tissues and can therefore be used to optimize and control PEF treatments. Public Library of Science 2011-06-13 /pmc/articles/PMC3113852/ /pubmed/21695144 http://dx.doi.org/10.1371/journal.pone.0020877 Text en Daniels, Rubinsky. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Daniels, Charlotte S. Rubinsky, Boris Temperature Modulation of Electric Fields in Biological Matter |
title | Temperature Modulation of Electric Fields in Biological Matter |
title_full | Temperature Modulation of Electric Fields in Biological Matter |
title_fullStr | Temperature Modulation of Electric Fields in Biological Matter |
title_full_unstemmed | Temperature Modulation of Electric Fields in Biological Matter |
title_short | Temperature Modulation of Electric Fields in Biological Matter |
title_sort | temperature modulation of electric fields in biological matter |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113852/ https://www.ncbi.nlm.nih.gov/pubmed/21695144 http://dx.doi.org/10.1371/journal.pone.0020877 |
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