Efficient Immunoglobulin Gene Disruption and Targeted Replacement in Rabbit Using Zinc Finger Nucleases

Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a chosen gene by mutagenesis and also mediate precise homologous recombination with a...

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Detalles Bibliográficos
Autores principales: Flisikowska, Tatiana, Thorey, Irmgard S., Offner, Sonja, Ros, Francesca, Lifke, Valeria, Zeitler, Bryan, Rottmann, Oswald, Vincent, Anna, Zhang, Lei, Jenkins, Shirin, Niersbach, Helmut, Kind, Alexander J., Gregory, Philip D., Schnieke, Angelika E., Platzer, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113902/
https://www.ncbi.nlm.nih.gov/pubmed/21695153
http://dx.doi.org/10.1371/journal.pone.0021045

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