EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis

BACKGROUND: Elastin microfibril interface located protein 2 (EMILIN2) is an extracellular glycoprotein associated with cardiovascular development. While other EMILIN proteins are reported to play a role in elastogenesis and coagulation, little is known about EMILIN2 function in the cardiovascular sy...

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Autores principales: Sa, Qila, Hoover-Plow, Jane L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113922/
https://www.ncbi.nlm.nih.gov/pubmed/21569335
http://dx.doi.org/10.1186/1477-9560-9-9
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author Sa, Qila
Hoover-Plow, Jane L
author_facet Sa, Qila
Hoover-Plow, Jane L
author_sort Sa, Qila
collection PubMed
description BACKGROUND: Elastin microfibril interface located protein 2 (EMILIN2) is an extracellular glycoprotein associated with cardiovascular development. While other EMILIN proteins are reported to play a role in elastogenesis and coagulation, little is known about EMILIN2 function in the cardiovascular system. The objective of this study was to determine whether EMILIN2 could play a role in thrombosis. RESULTS: EMILIN2 mRNA was expressed in 8 wk old C57BL/6J mice in lung, heart, aorta and bone marrow, with the highest expression in bone marrow. In mouse cells, EMILIN2 mRNA expression in macrophages was higher than expression in endothelial cells and fibroblasts. EMILIN2 was identified with cells and extracellular matrix by immunohistochemistry in the carotid and aorta. After carotid ferric chloride injury, EMILIN2 was abundantly expressed in the thrombus and inhibition of EMILIN2 increased platelet de-aggregation after ADP-stimulated platelet aggregation. CONCLUSIONS: These results suggest EMILIN2 could play a role in thrombosis as a constituent of the vessel wall and/or a component of the thrombus.
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spelling pubmed-31139222011-06-14 EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis Sa, Qila Hoover-Plow, Jane L Thromb J Original Basic Research BACKGROUND: Elastin microfibril interface located protein 2 (EMILIN2) is an extracellular glycoprotein associated with cardiovascular development. While other EMILIN proteins are reported to play a role in elastogenesis and coagulation, little is known about EMILIN2 function in the cardiovascular system. The objective of this study was to determine whether EMILIN2 could play a role in thrombosis. RESULTS: EMILIN2 mRNA was expressed in 8 wk old C57BL/6J mice in lung, heart, aorta and bone marrow, with the highest expression in bone marrow. In mouse cells, EMILIN2 mRNA expression in macrophages was higher than expression in endothelial cells and fibroblasts. EMILIN2 was identified with cells and extracellular matrix by immunohistochemistry in the carotid and aorta. After carotid ferric chloride injury, EMILIN2 was abundantly expressed in the thrombus and inhibition of EMILIN2 increased platelet de-aggregation after ADP-stimulated platelet aggregation. CONCLUSIONS: These results suggest EMILIN2 could play a role in thrombosis as a constituent of the vessel wall and/or a component of the thrombus. BioMed Central 2011-05-11 /pmc/articles/PMC3113922/ /pubmed/21569335 http://dx.doi.org/10.1186/1477-9560-9-9 Text en Copyright ©2011 Sa and Hoover-Plow; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Basic Research
Sa, Qila
Hoover-Plow, Jane L
EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis
title EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis
title_full EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis
title_fullStr EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis
title_full_unstemmed EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis
title_short EMILIN2 (Elastin microfibril interface located protein), potential modifier of thrombosis
title_sort emilin2 (elastin microfibril interface located protein), potential modifier of thrombosis
topic Original Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113922/
https://www.ncbi.nlm.nih.gov/pubmed/21569335
http://dx.doi.org/10.1186/1477-9560-9-9
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