The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains

BACKGROUND: The Q151M multi-drug resistance (MDR) pathway in HIV-1 reverse transcriptase (RT) confers reduced susceptibility to all nucleoside reverse transcriptase inhibitors (NRTIs) excluding tenofovir (TDF). This pathway emerges after long term failure of therapy, and is increasingly observed in...

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Detalles Bibliográficos
Autores principales: Mbisa, Jean L, Gupta, Ravi K, Kabamba, Desire, Mulenga, Veronica, Kalumbi, Moxmalama, Chintu, Chifumbe, Parry, Chris M, Gibb, Diana M, Walker, Sarah A, Cane, Patricia A, Pillay, Deenan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113953/
https://www.ncbi.nlm.nih.gov/pubmed/21569325
http://dx.doi.org/10.1186/1742-4690-8-31

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