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Diastolic myofilament dysfunction in the failing human heart
In recent years, it has become evident that heart failure is not solely due to reduced contractile performance of the heart muscle as impaired relaxation is evident in almost all heart failure patients. In more than half of all heart failure patients, diastolic dysfunction is the major cardiac defic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer-Verlag
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114087/ https://www.ncbi.nlm.nih.gov/pubmed/21487693 http://dx.doi.org/10.1007/s00424-011-0960-3 |
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author | van der Velden, Jolanda |
author_facet | van der Velden, Jolanda |
author_sort | van der Velden, Jolanda |
collection | PubMed |
description | In recent years, it has become evident that heart failure is not solely due to reduced contractile performance of the heart muscle as impaired relaxation is evident in almost all heart failure patients. In more than half of all heart failure patients, diastolic dysfunction is the major cardiac deficit. These heart failure patients have normal (or preserved) left ventricular ejection fraction, but impaired diastolic function evident from increased left ventricular end-diastolic pressure. Perturbations at the cellular level which cause impaired relaxation of the heart muscle involve changes in Ca(2+)-handling proteins, extracellular matrix components, and myofilament properties. The present review discusses the deficits in myofilament function observed in human heart failure and the most likely underlying causal protein changes. Moreover, the consequences of impaired myofilament function for in vivo diastolic dysfunction are discussed taking into account the reported changes in Ca(2+) handling. |
format | Online Article Text |
id | pubmed-3114087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-31140872011-07-14 Diastolic myofilament dysfunction in the failing human heart van der Velden, Jolanda Pflugers Arch Invited Review In recent years, it has become evident that heart failure is not solely due to reduced contractile performance of the heart muscle as impaired relaxation is evident in almost all heart failure patients. In more than half of all heart failure patients, diastolic dysfunction is the major cardiac deficit. These heart failure patients have normal (or preserved) left ventricular ejection fraction, but impaired diastolic function evident from increased left ventricular end-diastolic pressure. Perturbations at the cellular level which cause impaired relaxation of the heart muscle involve changes in Ca(2+)-handling proteins, extracellular matrix components, and myofilament properties. The present review discusses the deficits in myofilament function observed in human heart failure and the most likely underlying causal protein changes. Moreover, the consequences of impaired myofilament function for in vivo diastolic dysfunction are discussed taking into account the reported changes in Ca(2+) handling. Springer-Verlag 2011-04-13 2011 /pmc/articles/PMC3114087/ /pubmed/21487693 http://dx.doi.org/10.1007/s00424-011-0960-3 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Invited Review van der Velden, Jolanda Diastolic myofilament dysfunction in the failing human heart |
title | Diastolic myofilament dysfunction in the failing human heart |
title_full | Diastolic myofilament dysfunction in the failing human heart |
title_fullStr | Diastolic myofilament dysfunction in the failing human heart |
title_full_unstemmed | Diastolic myofilament dysfunction in the failing human heart |
title_short | Diastolic myofilament dysfunction in the failing human heart |
title_sort | diastolic myofilament dysfunction in the failing human heart |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114087/ https://www.ncbi.nlm.nih.gov/pubmed/21487693 http://dx.doi.org/10.1007/s00424-011-0960-3 |
work_keys_str_mv | AT vanderveldenjolanda diastolicmyofilamentdysfunctioninthefailinghumanheart |