Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice

Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with autosomal dominant inheritance of disease in humans. Similarly, mice that contain a single mutant APC gene encoding a protein truncated at re...

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Detalles Bibliográficos
Autores principales: Mohammad, H P, Zhang, W, Prevas, H S, Leadem, B R, Zhang, M, Herman, J G, Hooker, C M, Watkins, D N, Karim, B, Huso, D L, Baylin, S B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114184/
https://www.ncbi.nlm.nih.gov/pubmed/21297660
http://dx.doi.org/10.1038/onc.2010.633

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