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In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model
Since neovascularization has been reported that it is associated with tendinopathy, assessments of vascularity are important for both diagnosis and treatment estimation. Photoacoustic imaging, taking the advantages of good ultrasonic resolution and high optical absorption contrast, has been shown a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114215/ https://www.ncbi.nlm.nih.gov/pubmed/21698010 http://dx.doi.org/10.1364/BOE.2.001462 |
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author | Wang, Po-Hsun Luh, Jer-Junn Chen, Wen-Shiang Li, Meng-Lin |
author_facet | Wang, Po-Hsun Luh, Jer-Junn Chen, Wen-Shiang Li, Meng-Lin |
author_sort | Wang, Po-Hsun |
collection | PubMed |
description | Since neovascularization has been reported that it is associated with tendinopathy, assessments of vascularity are important for both diagnosis and treatment estimation. Photoacoustic imaging, taking the advantages of good ultrasonic resolution and high optical absorption contrast, has been shown a promising tool for vascular imaging. In this study, we explore the feasibility of photoacoustic micro-imaging in noninvasive monitoring of microvascular changes in Achilles tendon injuries on a mouse model in vivo. During collagenase-induced tendinitis, a 25-MHz photoacoustic microscope was used to image microvascular changes in Achilles tendons of mice longitudinally up to 23 days. In addition, complementary tissue structural information was revealed by collateral 25-MHz ultrasound microscopy. Morphological changes and proliferation of new blood vessels in Achilles tendons were observed during and after the acute inflammation. Observed microvascular changes during tendinitis were similar to the findings in the literatures. This study demonstrates that photoacoustic imaging can potentially be a complementary tool for high sensitive diagnosis and assessment of treatment performance in tendinopathy. |
format | Online Article Text |
id | pubmed-3114215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-31142152011-06-22 In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model Wang, Po-Hsun Luh, Jer-Junn Chen, Wen-Shiang Li, Meng-Lin Biomed Opt Express Photoacoustic Imaging and Spectroscopy Since neovascularization has been reported that it is associated with tendinopathy, assessments of vascularity are important for both diagnosis and treatment estimation. Photoacoustic imaging, taking the advantages of good ultrasonic resolution and high optical absorption contrast, has been shown a promising tool for vascular imaging. In this study, we explore the feasibility of photoacoustic micro-imaging in noninvasive monitoring of microvascular changes in Achilles tendon injuries on a mouse model in vivo. During collagenase-induced tendinitis, a 25-MHz photoacoustic microscope was used to image microvascular changes in Achilles tendons of mice longitudinally up to 23 days. In addition, complementary tissue structural information was revealed by collateral 25-MHz ultrasound microscopy. Morphological changes and proliferation of new blood vessels in Achilles tendons were observed during and after the acute inflammation. Observed microvascular changes during tendinitis were similar to the findings in the literatures. This study demonstrates that photoacoustic imaging can potentially be a complementary tool for high sensitive diagnosis and assessment of treatment performance in tendinopathy. Optical Society of America 2011-05-09 /pmc/articles/PMC3114215/ /pubmed/21698010 http://dx.doi.org/10.1364/BOE.2.001462 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Photoacoustic Imaging and Spectroscopy Wang, Po-Hsun Luh, Jer-Junn Chen, Wen-Shiang Li, Meng-Lin In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model |
title | In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model |
title_full | In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model |
title_fullStr | In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model |
title_full_unstemmed | In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model |
title_short | In vivo photoacoustic micro-imaging of microvascular changes for Achilles tendon injury on a mouse model |
title_sort | in vivo photoacoustic micro-imaging of microvascular changes for achilles tendon injury on a mouse model |
topic | Photoacoustic Imaging and Spectroscopy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114215/ https://www.ncbi.nlm.nih.gov/pubmed/21698010 http://dx.doi.org/10.1364/BOE.2.001462 |
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