Diabetic Peripheral Neuropathy Is Associated With Increased Arterial Stiffness Without Changes in Carotid Intima–Media Thickness in Type 2 Diabetes

OBJECTIVE: This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima–media thickness (IMT). RESEARCH DESIGN AND METHODS: We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on th...

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Detalles Bibliográficos
Autores principales: Kim, Eun Sook, Moon, Sung-dae, Kim, Hun-Sung, Lim, Dong Jun, Cho, Jae Hyoung, Kwon, Hyuk Sang, Ahn, Chul Woo, Yoon, Kun Ho, Kang, Moo Il, Cha, Bong Yun, Son, Ho Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114324/
https://www.ncbi.nlm.nih.gov/pubmed/21515840
http://dx.doi.org/10.2337/dc10-2222
Descripción
Sumario:OBJECTIVE: This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima–media thickness (IMT). RESEARCH DESIGN AND METHODS: We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS: Patients with DPN had higher CAVI than those without DPN in multivariate-adjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In the multivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13–1.65], P = 0.001). CONCLUSIONS: DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.

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