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Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer

Gefitinib and erlotinib, which are epidermal growth factor receptor- (EGFR-) specific tyrosine kinase inhibitors (TKIs), are widely used as molecularly targeted drugs for non-small-cell lung cancer (NSCLC). Currently, the search for EGFR gene mutations is becoming essential for the treatment of NSCL...

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Detalles Bibliográficos
Autores principales:	Kosaka, Takayuki, Yamaki, Ei, Mogi, Akira, Kuwano, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114474/ https://www.ncbi.nlm.nih.gov/pubmed/21687596 http://dx.doi.org/10.1155/2011/165214

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