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Varicocele-induced infertility: Newer insights into its pathophysiology
The association between varicoceles and male infertility has been known since the 1950s; however, the pathophysiology of the process remains uncertain. The primary proposed hypotheses involve hyperthermia, venous pressure, testicular blood flow, hormonal imbalance, toxic substances, and reactive oxy...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114589/ https://www.ncbi.nlm.nih.gov/pubmed/21716891 http://dx.doi.org/10.4103/0970-1591.78428 |
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author | Eisenberg, Michael L. Lipshultz, Larry I. |
author_facet | Eisenberg, Michael L. Lipshultz, Larry I. |
author_sort | Eisenberg, Michael L. |
collection | PubMed |
description | The association between varicoceles and male infertility has been known since the 1950s; however, the pathophysiology of the process remains uncertain. The primary proposed hypotheses involve hyperthermia, venous pressure, testicular blood flow, hormonal imbalance, toxic substances, and reactive oxygen species. It is difficult to identify a single or dominant factor, and it is likely that many of these factors contribute to the infertile phenotype seen in clinical practice. Moreover, patient lifestyle and genetic factors likely affect patient susceptibilities to the varicocele insult. While the current studies have weaknesses, they provide building blocks for futures studies into the pathophysiology of the varicocele. |
format | Online Article Text |
id | pubmed-3114589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31145892011-06-28 Varicocele-induced infertility: Newer insights into its pathophysiology Eisenberg, Michael L. Lipshultz, Larry I. Indian J Urol Symposium The association between varicoceles and male infertility has been known since the 1950s; however, the pathophysiology of the process remains uncertain. The primary proposed hypotheses involve hyperthermia, venous pressure, testicular blood flow, hormonal imbalance, toxic substances, and reactive oxygen species. It is difficult to identify a single or dominant factor, and it is likely that many of these factors contribute to the infertile phenotype seen in clinical practice. Moreover, patient lifestyle and genetic factors likely affect patient susceptibilities to the varicocele insult. While the current studies have weaknesses, they provide building blocks for futures studies into the pathophysiology of the varicocele. Medknow Publications 2011 /pmc/articles/PMC3114589/ /pubmed/21716891 http://dx.doi.org/10.4103/0970-1591.78428 Text en Copyright: © Indian Journal of Urology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Symposium Eisenberg, Michael L. Lipshultz, Larry I. Varicocele-induced infertility: Newer insights into its pathophysiology |
title | Varicocele-induced infertility: Newer insights into its pathophysiology |
title_full | Varicocele-induced infertility: Newer insights into its pathophysiology |
title_fullStr | Varicocele-induced infertility: Newer insights into its pathophysiology |
title_full_unstemmed | Varicocele-induced infertility: Newer insights into its pathophysiology |
title_short | Varicocele-induced infertility: Newer insights into its pathophysiology |
title_sort | varicocele-induced infertility: newer insights into its pathophysiology |
topic | Symposium |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114589/ https://www.ncbi.nlm.nih.gov/pubmed/21716891 http://dx.doi.org/10.4103/0970-1591.78428 |
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