Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

Hedgehog (Hh) signaling regulates embryonic development and adult tissue homeostasis through the GPCR-like protein Smoothened (Smo), but how vertebrate Smo is activated remains poorly understood. In Drosophila, Hh dependent phosphorylation activates Smo. Whether this is also the case in vertebrates...

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Detalles Bibliográficos
Autores principales: Chen, Yongbin, Sasai, Noriaki, Ma, Guoqiang, Yue, Tao, Jia, Jianhang, Briscoe, James, Jiang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114773/
https://www.ncbi.nlm.nih.gov/pubmed/21695114
http://dx.doi.org/10.1371/journal.pbio.1001083

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