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Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
Hedgehog (Hh) signaling regulates embryonic development and adult tissue homeostasis through the GPCR-like protein Smoothened (Smo), but how vertebrate Smo is activated remains poorly understood. In Drosophila, Hh dependent phosphorylation activates Smo. Whether this is also the case in vertebrates...
Autores principales: | Chen, Yongbin, Sasai, Noriaki, Ma, Guoqiang, Yue, Tao, Jia, Jianhang, Briscoe, James, Jiang, Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114773/ https://www.ncbi.nlm.nih.gov/pubmed/21695114 http://dx.doi.org/10.1371/journal.pbio.1001083 |
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