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Growth of breast cancer recurrences assessed by consecutive MRI

BACKGROUND: Women with a personal history of breast cancer have a high risk of developing an ipsi- or contralateral recurrence. We aimed to compare the growth rate of primary breast cancer and recurrences in women who had undergone prior breast magnetic resonance imaging (MRI). METHODS: Three hundre...

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Autores principales: Millet, Ingrid, Bouic-Pages, Emmanuelle, Hoa, Denis, Azria, David, Taourel, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114791/
https://www.ncbi.nlm.nih.gov/pubmed/21527002
http://dx.doi.org/10.1186/1471-2407-11-155
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author Millet, Ingrid
Bouic-Pages, Emmanuelle
Hoa, Denis
Azria, David
Taourel, Patrice
author_facet Millet, Ingrid
Bouic-Pages, Emmanuelle
Hoa, Denis
Azria, David
Taourel, Patrice
author_sort Millet, Ingrid
collection PubMed
description BACKGROUND: Women with a personal history of breast cancer have a high risk of developing an ipsi- or contralateral recurrence. We aimed to compare the growth rate of primary breast cancer and recurrences in women who had undergone prior breast magnetic resonance imaging (MRI). METHODS: Three hundred and sixty-two women were diagnosed with breast cancer and had undergone breast MRI at the time of diagnosis in our institution (2005 - 2009). Among them, 37 had at least one prior breast MRI with the lesion being visible but not diagnosed as cancer. A linear regression of tumour volume measured on MRI scans and time data was performed using a generalized logistic model to calculate growth rates. The primary objective was to compare the tumour growth rate of patients with either primary breast cancer (no history of breast cancer) or ipsi- or contralateral recurrences of breast cancer. RESULTS: Twenty women had no history of breast cancer and 17 patients were diagnosed as recurrences (7 and 10 were ipsi- and contralateral, respectively). The tumour growth rate was higher in contralateral recurrences than in ipsilateral recurrences (growth rate [10(-3 )days(-1)] 3.56 vs 1.38, p < .001) or primary cancer (3.56 vs 2.09, p = 0.01). Differences in tumour growth were not significant for other patient-, tumour- or treatment-related characteristics. CONCLUSIONS: These findings suggest that contralateral breast cancer presents accelerated growth compared to ipsilateral recurrences or primary breast events.
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spelling pubmed-31147912011-06-15 Growth of breast cancer recurrences assessed by consecutive MRI Millet, Ingrid Bouic-Pages, Emmanuelle Hoa, Denis Azria, David Taourel, Patrice BMC Cancer Research Article BACKGROUND: Women with a personal history of breast cancer have a high risk of developing an ipsi- or contralateral recurrence. We aimed to compare the growth rate of primary breast cancer and recurrences in women who had undergone prior breast magnetic resonance imaging (MRI). METHODS: Three hundred and sixty-two women were diagnosed with breast cancer and had undergone breast MRI at the time of diagnosis in our institution (2005 - 2009). Among them, 37 had at least one prior breast MRI with the lesion being visible but not diagnosed as cancer. A linear regression of tumour volume measured on MRI scans and time data was performed using a generalized logistic model to calculate growth rates. The primary objective was to compare the tumour growth rate of patients with either primary breast cancer (no history of breast cancer) or ipsi- or contralateral recurrences of breast cancer. RESULTS: Twenty women had no history of breast cancer and 17 patients were diagnosed as recurrences (7 and 10 were ipsi- and contralateral, respectively). The tumour growth rate was higher in contralateral recurrences than in ipsilateral recurrences (growth rate [10(-3 )days(-1)] 3.56 vs 1.38, p < .001) or primary cancer (3.56 vs 2.09, p = 0.01). Differences in tumour growth were not significant for other patient-, tumour- or treatment-related characteristics. CONCLUSIONS: These findings suggest that contralateral breast cancer presents accelerated growth compared to ipsilateral recurrences or primary breast events. BioMed Central 2011-04-28 /pmc/articles/PMC3114791/ /pubmed/21527002 http://dx.doi.org/10.1186/1471-2407-11-155 Text en Copyright ©2011 Millet et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Millet, Ingrid
Bouic-Pages, Emmanuelle
Hoa, Denis
Azria, David
Taourel, Patrice
Growth of breast cancer recurrences assessed by consecutive MRI
title Growth of breast cancer recurrences assessed by consecutive MRI
title_full Growth of breast cancer recurrences assessed by consecutive MRI
title_fullStr Growth of breast cancer recurrences assessed by consecutive MRI
title_full_unstemmed Growth of breast cancer recurrences assessed by consecutive MRI
title_short Growth of breast cancer recurrences assessed by consecutive MRI
title_sort growth of breast cancer recurrences assessed by consecutive mri
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114791/
https://www.ncbi.nlm.nih.gov/pubmed/21527002
http://dx.doi.org/10.1186/1471-2407-11-155
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