Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 (N6AMT1) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity

BACKGROUND: In humans, inorganic arsenic (iAs) is metabolized to methylated arsenical species in a multistep process mainly mediated by arsenic (+3 oxidation state) methyltransferase (AS3MT). Among these metabolites is monomethylarsonous acid (MMA(III)), the most toxic arsenic species. A recent stud...

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Detalles Bibliográficos
Autores principales: Ren, Xuefeng, Aleshin, Maria, Jo, William J., Dills, Russel, Kalman, David A., Vulpe, Christopher D., Smith, Martyn T., Zhang, Luoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114810/
https://www.ncbi.nlm.nih.gov/pubmed/21193388
http://dx.doi.org/10.1289/ehp.1002733

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