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Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic

BACKGROUND: Previous studies have shown associations between air pollution and risk for lung cancer. OBJECTIVE: We investigated whether traffic and the concentration of nitrogen oxides (NO(x)) at the residence are associated with risk for lung cancer. METHODS: We identified 592 lung cancer cases in...

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Autores principales: Raaschou-Nielsen, Ole, Andersen, Zorana Jovanovic, Hvidberg, Martin, Jensen, Steen Solvang, Ketzel, Matthias, Sørensen, Mette, Loft, Steffen, Overvad, Kim, Tjønneland, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114823/
https://www.ncbi.nlm.nih.gov/pubmed/21227886
http://dx.doi.org/10.1289/ehp.1002353
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author Raaschou-Nielsen, Ole
Andersen, Zorana Jovanovic
Hvidberg, Martin
Jensen, Steen Solvang
Ketzel, Matthias
Sørensen, Mette
Loft, Steffen
Overvad, Kim
Tjønneland, Anne
author_facet Raaschou-Nielsen, Ole
Andersen, Zorana Jovanovic
Hvidberg, Martin
Jensen, Steen Solvang
Ketzel, Matthias
Sørensen, Mette
Loft, Steffen
Overvad, Kim
Tjønneland, Anne
author_sort Raaschou-Nielsen, Ole
collection PubMed
description BACKGROUND: Previous studies have shown associations between air pollution and risk for lung cancer. OBJECTIVE: We investigated whether traffic and the concentration of nitrogen oxides (NO(x)) at the residence are associated with risk for lung cancer. METHODS: We identified 592 lung cancer cases in the Danish Cancer Registry among 52,970 members of the Diet, Cancer and Health cohort and traced residential addresses from 1 January 1971 in the Central Population Registry. We calculated the NO(x) concentration at each address by dispersion models and calculated the time-weighted average concentration for all addresses for each person. We used Cox models to estimate incidence rate ratios (IRRs) after adjustment for smoking (status, duration, and intensity), environmental tobacco smoke, length of school attendance, occupation, and dietary intake of fruit. RESULTS: For the highest compared with the lowest quartile of NO(x) concentration at the residence, we found an IRR for lung cancer of 1.30 [95% confidence interval (CI), 1.05–1.61], and the IRR for lung cancer in association with living within 50 m of a major road (> 10,000 vehicles/day) was 1.21 (95% CI, 0.95–1.55). The results showed tendencies of stronger associations among nonsmokers, among those with a relatively low fruit intake, and among those with a longer school attendance; only length of school attendance modified the effect significantly. CONCLUSIONS: This study supports that risk for lung cancer is associated with different markers of air pollution from traffic near the residence.
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spelling pubmed-31148232011-06-16 Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic Raaschou-Nielsen, Ole Andersen, Zorana Jovanovic Hvidberg, Martin Jensen, Steen Solvang Ketzel, Matthias Sørensen, Mette Loft, Steffen Overvad, Kim Tjønneland, Anne Environ Health Perspect Research BACKGROUND: Previous studies have shown associations between air pollution and risk for lung cancer. OBJECTIVE: We investigated whether traffic and the concentration of nitrogen oxides (NO(x)) at the residence are associated with risk for lung cancer. METHODS: We identified 592 lung cancer cases in the Danish Cancer Registry among 52,970 members of the Diet, Cancer and Health cohort and traced residential addresses from 1 January 1971 in the Central Population Registry. We calculated the NO(x) concentration at each address by dispersion models and calculated the time-weighted average concentration for all addresses for each person. We used Cox models to estimate incidence rate ratios (IRRs) after adjustment for smoking (status, duration, and intensity), environmental tobacco smoke, length of school attendance, occupation, and dietary intake of fruit. RESULTS: For the highest compared with the lowest quartile of NO(x) concentration at the residence, we found an IRR for lung cancer of 1.30 [95% confidence interval (CI), 1.05–1.61], and the IRR for lung cancer in association with living within 50 m of a major road (> 10,000 vehicles/day) was 1.21 (95% CI, 0.95–1.55). The results showed tendencies of stronger associations among nonsmokers, among those with a relatively low fruit intake, and among those with a longer school attendance; only length of school attendance modified the effect significantly. CONCLUSIONS: This study supports that risk for lung cancer is associated with different markers of air pollution from traffic near the residence. National Institute of Environmental Health Sciences 2011-06 2011-01-12 /pmc/articles/PMC3114823/ /pubmed/21227886 http://dx.doi.org/10.1289/ehp.1002353 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Raaschou-Nielsen, Ole
Andersen, Zorana Jovanovic
Hvidberg, Martin
Jensen, Steen Solvang
Ketzel, Matthias
Sørensen, Mette
Loft, Steffen
Overvad, Kim
Tjønneland, Anne
Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic
title Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic
title_full Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic
title_fullStr Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic
title_full_unstemmed Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic
title_short Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic
title_sort lung cancer incidence and long-term exposure to air pollution from traffic
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114823/
https://www.ncbi.nlm.nih.gov/pubmed/21227886
http://dx.doi.org/10.1289/ehp.1002353
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