Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

Germline mutations of FH, the gene that encodes for the tricarboxylic acid TCA (TCA) cycle enzyme fumarate hydratase, are associated with an inherited form of cancer referred to as Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC). Individuals with HLRCC are predisposed to the development of h...

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Detalles Bibliográficos
Autores principales: Sudarshan, Sunil, Shanmugasundaram, Karthigayan, Naylor, Susan L., Lin, Shu, Livi, Carolina B., O'Neill, Christine F., Parekh, Dipen J., Yeh, I-Tien, Sun, Lu-Zhe, Block, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114862/
https://www.ncbi.nlm.nih.gov/pubmed/21695080
http://dx.doi.org/10.1371/journal.pone.0021037

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