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Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer

PURPOSE: Vitamin D deficiency may be an indicator of poor prognosis in patients with breast cancer before surgery. We investigated the association between serum vitamin D concentration and breast cancer prognosis according to intrinsic cancer subtypes. METHODS: From June to December 2006, serum 25-O...

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Autores principales: Kim, Hee Jeong, Lee, Yu Mi, Ko, Beon Seok, Lee, Jong Won, Yu, Jong Han, Son, Byung Ho, Gong, Gyung-Yub, Kim, Sung Bae, Ahn, Sei Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115047/
https://www.ncbi.nlm.nih.gov/pubmed/21573699
http://dx.doi.org/10.1245/s10434-010-1465-6
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author Kim, Hee Jeong
Lee, Yu Mi
Ko, Beon Seok
Lee, Jong Won
Yu, Jong Han
Son, Byung Ho
Gong, Gyung-Yub
Kim, Sung Bae
Ahn, Sei Hyun
author_facet Kim, Hee Jeong
Lee, Yu Mi
Ko, Beon Seok
Lee, Jong Won
Yu, Jong Han
Son, Byung Ho
Gong, Gyung-Yub
Kim, Sung Bae
Ahn, Sei Hyun
author_sort Kim, Hee Jeong
collection PubMed
description PURPOSE: Vitamin D deficiency may be an indicator of poor prognosis in patients with breast cancer before surgery. We investigated the association between serum vitamin D concentration and breast cancer prognosis according to intrinsic cancer subtypes. METHODS: From June to December 2006, serum 25-OHD was measured in 310 Korean women with breast cancer who were treated at the Asan Medical Center, Korea. Clinicopathologic data were examined to determine the prognostic effects of serum 25-OHD. Expression of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (Her2) were measured using tissue microarrays. Patients were classified with luminal A, luminal B, Her2-enriched, or basal-like subtypes of breast cancer. RESULTS: Mean patient age was 48.7 years, and mean serum 25-OHD concentration was 31.4 ± 16.1 ng/ml. The 25-OHD levels were deficient (< 20 ng/ml) in 75 patients (24.2%), insufficient (20–29 ng/ml) in 95 (30.6%), and sufficient (30–150 ng/ml) in 140 (45.2%). Women with deficient 25-OHD levels were at increased risk of recurrence compared with those with sufficient vitamin D levels (P = 0.002). The 25-OHD concentration was inversely associated with prognosis of patients with cancer of the luminal A (P = 0.012) and luminal B subtypes (P = 0.023), but not with the prognosis of patients with Her2/neu-enriched (P = 0.245) or triple-negative (P = 0.879) cancer subtypes. This association remained valid after adjustment for age, tumor size, nodal status, and estrogen receptor status (hazards ratio = 3.97; 95% confidence interval = 1.77–9.61). CONCLUSIONS: Vitamin D deficiency may be associated with poor outcomes in patients with luminal-type breast cancer.
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spelling pubmed-31150472011-07-14 Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer Kim, Hee Jeong Lee, Yu Mi Ko, Beon Seok Lee, Jong Won Yu, Jong Han Son, Byung Ho Gong, Gyung-Yub Kim, Sung Bae Ahn, Sei Hyun Ann Surg Oncol Breast Oncology PURPOSE: Vitamin D deficiency may be an indicator of poor prognosis in patients with breast cancer before surgery. We investigated the association between serum vitamin D concentration and breast cancer prognosis according to intrinsic cancer subtypes. METHODS: From June to December 2006, serum 25-OHD was measured in 310 Korean women with breast cancer who were treated at the Asan Medical Center, Korea. Clinicopathologic data were examined to determine the prognostic effects of serum 25-OHD. Expression of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (Her2) were measured using tissue microarrays. Patients were classified with luminal A, luminal B, Her2-enriched, or basal-like subtypes of breast cancer. RESULTS: Mean patient age was 48.7 years, and mean serum 25-OHD concentration was 31.4 ± 16.1 ng/ml. The 25-OHD levels were deficient (< 20 ng/ml) in 75 patients (24.2%), insufficient (20–29 ng/ml) in 95 (30.6%), and sufficient (30–150 ng/ml) in 140 (45.2%). Women with deficient 25-OHD levels were at increased risk of recurrence compared with those with sufficient vitamin D levels (P = 0.002). The 25-OHD concentration was inversely associated with prognosis of patients with cancer of the luminal A (P = 0.012) and luminal B subtypes (P = 0.023), but not with the prognosis of patients with Her2/neu-enriched (P = 0.245) or triple-negative (P = 0.879) cancer subtypes. This association remained valid after adjustment for age, tumor size, nodal status, and estrogen receptor status (hazards ratio = 3.97; 95% confidence interval = 1.77–9.61). CONCLUSIONS: Vitamin D deficiency may be associated with poor outcomes in patients with luminal-type breast cancer. Springer-Verlag 2010-12-14 2011 /pmc/articles/PMC3115047/ /pubmed/21573699 http://dx.doi.org/10.1245/s10434-010-1465-6 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Breast Oncology
Kim, Hee Jeong
Lee, Yu Mi
Ko, Beon Seok
Lee, Jong Won
Yu, Jong Han
Son, Byung Ho
Gong, Gyung-Yub
Kim, Sung Bae
Ahn, Sei Hyun
Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer
title Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer
title_full Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer
title_fullStr Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer
title_full_unstemmed Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer
title_short Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer
title_sort vitamin d deficiency is correlated with poor outcomes in patients with luminal-type breast cancer
topic Breast Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115047/
https://www.ncbi.nlm.nih.gov/pubmed/21573699
http://dx.doi.org/10.1245/s10434-010-1465-6
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