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Recent Advances in Brain Physiology and Cognitive Processing****

The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integratio...

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Detalles Bibliográficos
Autores principales: Alfredo, Pereira, Pereira, Maria Alice Ornellas, Furlan, Fábio Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115287/
https://www.ncbi.nlm.nih.gov/pubmed/21694969
http://dx.doi.org/10.4103/0973-1229.77434
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author Alfredo, Pereira
Pereira, Maria Alice Ornellas
Furlan, Fábio Augusto
author_facet Alfredo, Pereira
Pereira, Maria Alice Ornellas
Furlan, Fábio Augusto
author_sort Alfredo, Pereira
collection PubMed
description The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular calcium waves that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena.
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spelling pubmed-31152872011-06-21 Recent Advances in Brain Physiology and Cognitive Processing**** Alfredo, Pereira Pereira, Maria Alice Ornellas Furlan, Fábio Augusto Mens Sana Monogr Brain, Mind and Consciousness The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular calcium waves that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. Medknow Publications 2011 /pmc/articles/PMC3115287/ /pubmed/21694969 http://dx.doi.org/10.4103/0973-1229.77434 Text en © Mens Sana Monographs http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brain, Mind and Consciousness
Alfredo, Pereira
Pereira, Maria Alice Ornellas
Furlan, Fábio Augusto
Recent Advances in Brain Physiology and Cognitive Processing****
title Recent Advances in Brain Physiology and Cognitive Processing****
title_full Recent Advances in Brain Physiology and Cognitive Processing****
title_fullStr Recent Advances in Brain Physiology and Cognitive Processing****
title_full_unstemmed Recent Advances in Brain Physiology and Cognitive Processing****
title_short Recent Advances in Brain Physiology and Cognitive Processing****
title_sort recent advances in brain physiology and cognitive processing****
topic Brain, Mind and Consciousness
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115287/
https://www.ncbi.nlm.nih.gov/pubmed/21694969
http://dx.doi.org/10.4103/0973-1229.77434
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