A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient

We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,X...

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Autores principales: Kim, Min Jin, Cho, Sun Young, Lim, Gayoung, Yoon, Hoi Soo, Lee, Hee Joo, Suh, Jin-Tae, Lee, Juhie, Lee, Woo-In, Cho, Kyung Sam, Park, Tae Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Laboratory Medicine 2011
Materias:
Diagnostic Hematology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116005/
https://www.ncbi.nlm.nih.gov/pubmed/21474981
http://dx.doi.org/10.3343/kjlm.2011.31.2.86
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author Kim, Min Jin
Cho, Sun Young
Lim, Gayoung
Yoon, Hoi Soo
Lee, Hee Joo
Suh, Jin-Tae
Lee, Juhie
Lee, Woo-In
Cho, Kyung Sam
Park, Tae Sung
author_facet Kim, Min Jin
Cho, Sun Young
Lim, Gayoung
Yoon, Hoi Soo
Lee, Hee Joo
Suh, Jin-Tae
Lee, Juhie
Lee, Woo-In
Cho, Kyung Sam
Park, Tae Sung
author_sort Kim, Min Jin
collection PubMed
description We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a dual color dual fusion translocation PML-RARA probe were consistent with the results of conventional cytogenetics. Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment response of APL cases are recommended.
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spelling pubmed-31160052011-07-14 A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient Kim, Min Jin Cho, Sun Young Lim, Gayoung Yoon, Hoi Soo Lee, Hee Joo Suh, Jin-Tae Lee, Juhie Lee, Woo-In Cho, Kyung Sam Park, Tae Sung Korean J Lab Med Diagnostic Hematology We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a dual color dual fusion translocation PML-RARA probe were consistent with the results of conventional cytogenetics. Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment response of APL cases are recommended. The Korean Society for Laboratory Medicine 2011-04 2011-03-31 /pmc/articles/PMC3116005/ /pubmed/21474981 http://dx.doi.org/10.3343/kjlm.2011.31.2.86 Text en Copyright © 2011 The Korean Society for Laboratory Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Diagnostic Hematology
Kim, Min Jin
Cho, Sun Young
Lim, Gayoung
Yoon, Hoi Soo
Lee, Hee Joo
Suh, Jin-Tae
Lee, Juhie
Lee, Woo-In
Cho, Kyung Sam
Park, Tae Sung
A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
title A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
title_full A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
title_fullStr A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
title_full_unstemmed A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
title_short A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
title_sort rare case of microgranular acute promyelocytic leukemia associated with ider(17)(q10)t(15;17) in an old-age patient
topic Diagnostic Hematology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116005/
https://www.ncbi.nlm.nih.gov/pubmed/21474981
http://dx.doi.org/10.3343/kjlm.2011.31.2.86
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