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Histone variant macroH2A confers resistance to nuclear reprogramming

How various layers of epigenetic repression restrict somatic cell nuclear reprogramming is poorly understood. The transfer of mammalian somatic cell nuclei into Xenopus oocytes induces transcriptional reprogramming of previously repressed genes. Here, we address the mechanisms that restrict reprogra...

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Detalles Bibliográficos
Autores principales: Pasque, Vincent, Gillich, Astrid, Garrett, Nigel, Gurdon, John B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116279/
https://www.ncbi.nlm.nih.gov/pubmed/21552206
http://dx.doi.org/10.1038/emboj.2011.144

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