Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form

A new, simple, precise and accurate high performance thin layer chromatographic method has been proposed for the determination of almotriptan malate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 GF(254) with butanol:acetic acid:water (3:1:1) was used...

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Detalles Bibliográficos
Autores principales: Suneetha, A., Syamasundar, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116310/
https://www.ncbi.nlm.nih.gov/pubmed/21694997
http://dx.doi.org/10.4103/0250-474X.78534
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author Suneetha, A.
Syamasundar, B.
author_facet Suneetha, A.
Syamasundar, B.
author_sort Suneetha, A.
collection PubMed
description A new, simple, precise and accurate high performance thin layer chromatographic method has been proposed for the determination of almotriptan malate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 GF(254) with butanol:acetic acid:water (3:1:1) was used as mobilephase. Quantitative analysis was performed by densitometric scanning at 300 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range of 100-700 ng/band for almotriptan malate. The method was successfully applied to the analysis of drug in a pharmaceutical dosage form.
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spelling pubmed-31163102011-06-21 Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form Suneetha, A. Syamasundar, B. Indian J Pharm Sci Short Communication A new, simple, precise and accurate high performance thin layer chromatographic method has been proposed for the determination of almotriptan malate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 GF(254) with butanol:acetic acid:water (3:1:1) was used as mobilephase. Quantitative analysis was performed by densitometric scanning at 300 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range of 100-700 ng/band for almotriptan malate. The method was successfully applied to the analysis of drug in a pharmaceutical dosage form. Medknow Publications 2010 /pmc/articles/PMC3116310/ /pubmed/21694997 http://dx.doi.org/10.4103/0250-474X.78534 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Suneetha, A.
Syamasundar, B.
Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form
title Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form
title_full Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form
title_fullStr Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form
title_full_unstemmed Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form
title_short Development and Validation of HPTLC Method for the Estimation of Almotriptan Malate in Tablet Dosage Form
title_sort development and validation of hptlc method for the estimation of almotriptan malate in tablet dosage form
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116310/
https://www.ncbi.nlm.nih.gov/pubmed/21694997
http://dx.doi.org/10.4103/0250-474X.78534
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