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Cardiac safety of indacaterol in healthy subjects: a randomized, multidose, placebo- and positive-controlled, parallel-group thorough QT study

BACKGROUND: Indacaterol is a novel once-daily ultra long-acting β(2)-agonist for the treatment of chronic obstructive pulmonary disease. It is known that β(2)-agonists, like other adrenergic compounds, can prolong the QT-interval. This thorough QT/QTc study (as per ICH E14 guideline) evaluated the e...

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Detalles Bibliográficos
Autores principales:	Khindri, Sanjeev, Sabo, Ronald, Harris, Stuart, Woessner, Ralph, Jennings, Simon, Drollmann, Anton F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116479/ https://www.ncbi.nlm.nih.gov/pubmed/21615886 http://dx.doi.org/10.1186/1471-2466-11-31

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