Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo

The aims of the study are to explore the effect of ursolic acid (UA) on the growth of gastric cancer cell line BGC-803 and hepatocellular cancer cell H22 xenograft and to understand the mechanism. UA inhibits growth of BGC-803 cells in vitro in dose-dependent and time-dependent manner. Treated with...

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Autores principales: Wang, Xuemei, Zhang, Fan, Yang, Ling, Mei, Ying, Long, Hai, Zhang, Xiaowen, Zhang, Jialing, Qimuge-Suyila, Su, Xiulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116524/
https://www.ncbi.nlm.nih.gov/pubmed/21716649
http://dx.doi.org/10.1155/2011/419343
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author Wang, Xuemei
Zhang, Fan
Yang, Ling
Mei, Ying
Long, Hai
Zhang, Xiaowen
Zhang, Jialing
Qimuge-Suyila,
Su, Xiulan
author_facet Wang, Xuemei
Zhang, Fan
Yang, Ling
Mei, Ying
Long, Hai
Zhang, Xiaowen
Zhang, Jialing
Qimuge-Suyila,
Su, Xiulan
author_sort Wang, Xuemei
collection PubMed
description The aims of the study are to explore the effect of ursolic acid (UA) on the growth of gastric cancer cell line BGC-803 and hepatocellular cancer cell H22 xenograft and to understand the mechanism. UA inhibits growth of BGC-803 cells in vitro in dose-dependent and time-dependent manner. Treated with UA in vivo, tumor cells can be arrested to G0/G1 stage. The apoptotic rate was significantly increased in tumor cells treated with UA both in vitro and in vivo. DNA fragmentation was found in BGC-803 cells exposed to UA. UA activated caspase-3, -8, and -9 and down regulated expression of Bcl-2 in BGC-803 cells. The expression of caspase-3 and -8 was elevated in tumor cells from xenograft treated with UA. (18)F-FLT PET-CT imaging confirmed tumor model and UA effectiveness. Our results indicated that UA inhibits growth of tumor cells both in vitro and in vivo by decreasing proliferation of cells and inducing apoptosis.
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spelling pubmed-31165242011-06-28 Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo Wang, Xuemei Zhang, Fan Yang, Ling Mei, Ying Long, Hai Zhang, Xiaowen Zhang, Jialing Qimuge-Suyila, Su, Xiulan J Biomed Biotechnol Research Article The aims of the study are to explore the effect of ursolic acid (UA) on the growth of gastric cancer cell line BGC-803 and hepatocellular cancer cell H22 xenograft and to understand the mechanism. UA inhibits growth of BGC-803 cells in vitro in dose-dependent and time-dependent manner. Treated with UA in vivo, tumor cells can be arrested to G0/G1 stage. The apoptotic rate was significantly increased in tumor cells treated with UA both in vitro and in vivo. DNA fragmentation was found in BGC-803 cells exposed to UA. UA activated caspase-3, -8, and -9 and down regulated expression of Bcl-2 in BGC-803 cells. The expression of caspase-3 and -8 was elevated in tumor cells from xenograft treated with UA. (18)F-FLT PET-CT imaging confirmed tumor model and UA effectiveness. Our results indicated that UA inhibits growth of tumor cells both in vitro and in vivo by decreasing proliferation of cells and inducing apoptosis. Hindawi Publishing Corporation 2011 2011-05-30 /pmc/articles/PMC3116524/ /pubmed/21716649 http://dx.doi.org/10.1155/2011/419343 Text en Copyright © 2011 Xuemei Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Xuemei
Zhang, Fan
Yang, Ling
Mei, Ying
Long, Hai
Zhang, Xiaowen
Zhang, Jialing
Qimuge-Suyila,
Su, Xiulan
Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
title Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
title_full Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
title_fullStr Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
title_full_unstemmed Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
title_short Ursolic Acid Inhibits Proliferation and Induces Apoptosis of Cancer Cells In Vitro and In Vivo
title_sort ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116524/
https://www.ncbi.nlm.nih.gov/pubmed/21716649
http://dx.doi.org/10.1155/2011/419343
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