Cargando…

Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains

Plasmodium falciparum, the causative agent of the most severe form of malaria in humans invades erythrocytes using multiple ligand-receptor interactions. The P. falciparum reticulocyte binding-like homologue proteins (PfRh or PfRBL) are important for entry of the invasive merozoite form of the paras...

Descripción completa

Detalles Bibliográficos
Autores principales:	Triglia, Tony, Chen, Lin, Lopaticki, Sash, Dekiwadia, Chaitali, Riglar, David T., Hodder, Anthony N., Ralph, Stuart A., Baum, Jake, Cowman, Alan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116812/ https://www.ncbi.nlm.nih.gov/pubmed/21698217 http://dx.doi.org/10.1371/journal.ppat.1002075

Ejemplares similares

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum
por: Chen, Lin, et al.
Publicado: (2011)

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion
por: Triglia, Tony, et al.
Publicado: (2023)

Antibodies Targeting the PfRH1 Binding Domain Inhibit Invasion of Plasmodium falciparum Merozoites
por: Gao, Xiaohong, et al.
Publicado: (2008)

Targeting PfRh5 on Merozoites to Prevent Basigin Binding
por: Papadopoulos, Konstantinos
Publicado: (2012)

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites
por: Weiss, Greta E., et al.
Publicado: (2023)

Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens
por: Williams, Andrew R., et al.
Publicado: (2012)

Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum
por: Engelberg, Klemens, et al.
Publicado: (2013)

Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte
por: Riglar, David, et al.
Publicado: (2010)

Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte
por: Riglar, David, et al.
Publicado: (2010)

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
por: Bustamante, Leyla Y., et al.
Publicado: (2013)

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes
por: Chen, Lin, et al.
Publicado: (2014)

Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria
por: Partey, Frederica D., et al.
Publicado: (2018)

Correction: Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria
por: Partey, Frederica D., et al.
Publicado: (2018)

A DNA Vaccine Encoding Plasmodium falciparum PfRH5 in Cationic Liposomes for Dermal Tattooing Immunization
por: Fotoran, Wesley Luzetti, et al.
Publicado: (2020)

PfRH5: A Novel Reticulocyte-Binding Family Homolog of Plasmodium falciparum that Binds to the Erythrocyte, and an Investigation of Its Receptor
por: Rodriguez, Marilis, et al.
Publicado: (2008)

Temporal changes in Plasmodium falciparum reticulocyte binding protein homolog 2b (PfRh2b) in Senegal and The Gambia
por: Diédhiou, Cyrille K., et al.
Publicado: (2019)

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum
por: Hodder, Anthony N, et al.
Publicado: (2008)

Correction: PfRH5: A Novel Reticulocyte-Binding Family Homolog of Plasmodium falciparum that Binds to the Erythrocyte, and an Investigation of Its Receptor
por: Rodriguez, Marilis, et al.
Publicado: (2008)

A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys
por: Douglas, Alexander D., et al.
Publicado: (2015)

Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast
por: Lemgruber, Leandro, et al.
Publicado: (2013)

Plasmodium falciparum Reticulocyte Binding-Like Homologue Protein 2 (PfRH2) Is a Key Adhesive Molecule Involved in Erythrocyte Invasion
por: Sahar, Tajali, et al.
Publicado: (2011)

Subclass responses and their half-lives for antibodies against EBA175 and PfRh2 in naturally acquired immunity against Plasmodium falciparum malaria
por: Ahmed Ismail, Hodan, et al.
Publicado: (2014)

Reticulocyte binding protein homologues are key adhesins during erythrocyte invasion by Plasmodium falciparum
por: Triglia, Tony, et al.
Publicado: (2009)

The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria
por: Weaver, Rupert, et al.
Publicado: (2016)

Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A
por: Nagaoka, Hikaru, et al.
Publicado: (2020)

PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes
por: Liffner, Benjamin, et al.
Publicado: (2020)

Invasion by P. falciparum Merozoites Suggests a Hierarchy of Molecular Interactions
por: Baum, Jake, et al.
Publicado: (2005)

Efficient Measurement of Opsonising Antibodies to Plasmodium falciparum Merozoites
por: Hill, Danika L., et al.
Publicado: (2012)

Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition
por: Moore, Adam J., et al.
Publicado: (2021)

Establishment of an Antiplasmodial Vaccine Based on PfRH5-Encoding RNA Replicons Stabilized by Cationic Liposomes
por: Fotoran, Wesley L., et al.
Publicado: (2023)

Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies
por: Miura, Kazutoyo, et al.
Publicado: (2023)

Evolution of Genetic Polymorphisms of Plasmodium falciparum Merozoite Surface Protein (PfMSP) in Thailand
por: Kuesap, Jiraporn, et al.
Publicado: (2014)

Structure-guided insights into potential function of novel genetic variants in the malaria vaccine candidate PfRh5
por: Mangou, Khadidiatou, et al.
Publicado: (2022)

Identification of a reticulocyte-specific binding domain of Plasmodium vivax reticulocyte-binding protein 1 that is homologous to the PfRh4 erythrocyte-binding domain
por: Han, Jin-Hee, et al.
Publicado: (2016)

Plasmodium falciparum Merozoite Associated Armadillo Protein (PfMAAP) Is Apically Localized in Free Merozoites and Antibodies Are Associated With Reduced Risk of Malaria
por: Aniweh, Yaw, et al.
Publicado: (2020)

Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes
por: Bargieri, Daniel Y., et al.
Publicado: (2016)

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum
por: Healer, Julie, et al.
Publicado: (2013)

Investigation of the Plasmodium falciparum Food Vacuole through Inducible Expression of the Chloroquine Resistance Transporter (PfCRT)
por: Ehlgen, Florian, et al.
Publicado: (2012)

Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites
por: Richard, Dave, et al.
Publicado: (2010)

The Plasmodium falciparum Erythrocyte Invasion Ligand Pfrh4 as a Target of Functional and Protective Human Antibodies against Malaria
por: Reiling, Linda, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_osaf5hb77lo47tupf6mrrtmd9v