Intestinal Activation of Notch Signaling Induces Rapid Onset Hepatic Steatosis and Insulin Resistance

Here we investigate the effects of expressing an activated mutant of Notch (ICD-E) in an inducible transgenic mouse model. Hepatic expression of ICD-E in adult animals has no detectable phenotype, but simultaneous induction of ICD-E in both the liver and small intestine results in hepatic steatosis,...

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Detalles Bibliográficos
Autores principales: Fowler, Joanna C., Zecchini, Vincent R., Jones, Philip H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116826/
https://www.ncbi.nlm.nih.gov/pubmed/21698231
http://dx.doi.org/10.1371/journal.pone.0020767

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