Cargando…

MMP-2 siRNA Inhibits Radiation-Enhanced Invasiveness in Glioma Cells

BACKGROUND: Our previous work and that of others strongly suggests a relationship between the infiltrative phenotype of gliomas and the expression of MMP-2. Radiation therapy, which represents one of the mainstays of glioma treatment, is known to increase cell invasion by inducing MMP-2. Thus, inhib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Badiga, Aruna Venkata, Chetty, Chandramu, Kesanakurti, Divya, Are, Deepthi, Gujrati, Meena, Klopfenstein, Jeffrey D., Dinh, Dzung H., Rao, Jasti S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116828/ https://www.ncbi.nlm.nih.gov/pubmed/21698233 http://dx.doi.org/10.1371/journal.pone.0020614

Ejemplares similares

Role of MMP-2 in the Regulation of IL-6/Stat3 Survival Signaling via Interaction With α5β1 Integrin in glioma
por: Kesanakurti, Divya, et al.
Publicado: (2012)

MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2010)

MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors
por: Bhoopathi, Praveen, et al.
Publicado: (2011)

Suppression of MMP-2 Attenuates TNF-α Induced NF-κB Activation and Leads to JNK Mediated Cell Death in Glioma
por: Kesanakurti, Divya, et al.
Publicado: (2011)

Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells
por: Ponnala, Shivani, et al.
Publicado: (2021)

MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling
por: MADDIRELA, DILIP RAJASEKHAR, et al.
Publicado: (2013)

Regulation of DNA Repair Mechanism in Human Glioma Xenograft Cells both In Vitro and In Vivo in Nude Mice
por: Ponnala, Shivani, et al.
Publicado: (2011)

Cord Blood Stem Cell-Mediated Induction of Apoptosis in Glioma Downregulates X-Linked Inhibitor of Apoptosis Protein (XIAP)
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma
por: Kesanakurti, D, et al.
Publicado: (2012)

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity
por: Asuthkar, Swapna, et al.
Publicado: (2012)

Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27(Kip1) Upregulation
por: Gopinath, Sreelatha, et al.
Publicado: (2010)

Cathepsin B and uPAR Knockdown Inhibits Tumor-induced Angiogenesis by Modulating VEGF Expression in Glioma
por: Malla, Rama Rao, et al.
Publicado: (2011)

uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells
por: Alapati, Kiranmai, et al.
Publicado: (2014)

Suppression of uPAR Retards Radiation-Induced Invasion and Migration Mediated by Integrin β1/FAK Signaling in Medulloblastoma
por: Nalla, Arun Kumar, et al.
Publicado: (2010)

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor
por: Raghu, Hari, et al.
Publicado: (2011)

Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
por: Malla, Ramarao, et al.
Publicado: (2010)

Correction: Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
por: Malla, Ramarao, et al.
Publicado: (2014)

Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo
por: Gupta, Reshu, et al.
Publicado: (2021)

Retraction: MMP-2 siRNA Inhibits Radiation-Enhanced Invasiveness in Glioma Cells
Publicado: (2020)

α3β1 integrin promotes radiation-induced migration of meningioma cells
por: Gogineni, Venkateswara Rao, et al.
Publicado: (2021)

Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines
por: Raghu, Hari, et al.
Publicado: (2010)

Temporal Regulation of Apoptotic and Anti-apoptotic Molecules After Middle Cerebral Artery Occlusion Followed by Reperfusion
por: Chelluboina, Bharath, et al.
Publicado: (2013)

The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine
por: Bhoopathi, P, et al.
Publicado: (2010)

Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1
por: Velpula, Kiran Kumar, et al.
Publicado: (2011)

MMP-9 and uPAR regulated glioma cell migration
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2012)

SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT
por: Bhoopathi, Praveen, et al.
Publicado: (2012)

Apoptosis Induced by Knockdown of uPAR and MMP-9 is Mediated by Inactivation of EGFR/STAT3 Signaling in Medulloblastoma
por: Kotipatruni, Ramaprasada Rao, et al.
Publicado: (2012)

Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration
por: Zhuang, Thompson, et al.
Publicado: (2013)

The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma
por: SAILAJA, G.S., et al.
Publicado: (2012)

A Novel Interaction of PAK4 with PPARγ to Regulate Nox1 and Radiation-Induced Epithelial-to-Mesenchymal Transition in Glioma
por: Kesanakurti, Divya, et al.
Publicado: (2017)

uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells
por: ALAPATI, KIRANMAI, et al.
Publicado: (2012)

Codelivery of temozolomide and siRNA with polymeric nanocarrier for effective glioma treatment
por: Peng, Yuan, et al.
Publicado: (2018)

Hypoxia-responsive ionizable liposome delivery siRNA for glioma therapy
por: Liu, Hong-Mei, et al.
Publicado: (2017)

Dual MMP7-Proximity-Activated and Folate Receptor-Targeted Nanoparticles for siRNA Delivery
por: Li, Hongmei, et al.
Publicado: (2014)

Regulation function of MMP-1 downregulated by siRNA on migration of heat-denatured dermal fibroblasts
por: He, Xianghui, et al.
Publicado: (2017)

Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine
por: Levine, Rachel M., et al.
Publicado: (2016)

Downregulation of Focal Adhesion Kinase (FAK) by cord blood stem cells inhibits angiogenesis in glioblastoma
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Intracranially injectable multi-siRNA nanomedicine for the inhibition of glioma stem cells
por: Manju, Cheripelil Abraham, et al.
Publicado: (2021)

The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma
por: Xu, Haoyue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6evbv9idkj572eni4h1k8a07t7