Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity

BACKGROUND: The type 2 iodothyronine deiodinase (D2) converts the pro-hormone thyroxine into T3 within target tissues. D2 is essential for a full thermogenic response of brown adipose tissue (BAT), and mice with a disrupted Dio2 gene (D2KO) have an impaired response to cold. BAT is also activated by...

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Detalles Bibliográficos
Autores principales: Marsili, Alessandro, Aguayo-Mazzucato, Cristina, Chen, Ting, Kumar, Aditi, Chung, Mirra, Lunsford, Elaine P., Harney, John W., Van-Tran, Thuy, Gianetti, Elena, Ramadan, Waile, Chou, Cyril, Bonner-Weir, Susan, Larsen, Philip Reed, Silva, Jorge Enrique, Zavacki, Ann Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116839/
https://www.ncbi.nlm.nih.gov/pubmed/21698184
http://dx.doi.org/10.1371/journal.pone.0020832

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