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Transgene Optimization, Immunogenicity and In Vitro Efficacy of Viral Vectored Vaccines Expressing Two Alleles of Plasmodium falciparum AMA1

BACKGROUND: Apical membrane antigen 1 (AMA1) is a leading candidate vaccine antigen against blood-stage malaria, although to date numerous clinical trials using mainly protein-in-adjuvant vaccines have shown limited success. Here we describe the pre-clinical development and optimization of recombina...

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Detalles Bibliográficos
Autores principales:	Biswas, Sumi, Dicks, Matthew D. J., Long, Carole A., Remarque, Edmond J., Siani, Loredana, Colloca, Stefano, Cottingham, Matthew G., Holder, Anthony A., Gilbert, Sarah C., Hill, Adrian V. S., Draper, Simon J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116848/ https://www.ncbi.nlm.nih.gov/pubmed/21698193 http://dx.doi.org/10.1371/journal.pone.0020977

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