Cargando…

Cten Is Targeted by Kras Signalling to Regulate Cell Motility in the Colon and Pancreas

CTEN/TNS4 is an oncogene in colorectal cancer (CRC) which enhances cell motility although the mechanism of Cten regulation is unknown. We found an association between high Cten expression and KRAS/BRAF mutation in a series of CRC cell lines (p = 0.03) and hypothesised that Kras may regulate Cten. To...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Ghamdi, Saleh, Albasri, Abdulkader, Cachat, Julien, Ibrahem, Salih, Muhammad, Belal A., Jackson, Darryl, Nateri, Abdolrahman S., Kindle, Karin B., Ilyas, Mohammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116852/ https://www.ncbi.nlm.nih.gov/pubmed/21698197 http://dx.doi.org/10.1371/journal.pone.0020919

Ejemplares similares

STAT3 paradoxically stimulates β-catenin expression but inhibits β-catenin function
por: Ibrahem, Salih, et al.
Publicado: (2014)

Epidermal growth factor receptor (EGFR) and Stat3 signal through Kras and have mutually opposite effects on Cten
por: AlGhamdi, Saleh, et al.
Publicado: (2014)

Tensin4 (TNS4) is upregulated by Wnt signalling in adenomas in multiple intestinal neoplasia (Min) mice
por: Raposo, Teresa P., et al.
Publicado: (2020)

Force-induced recruitment of cten along keratin network in epithelial cells
por: Cheah, Joleen S., et al.
Publicado: (2019)

Immunohistochemical Expression of Tensin-4/CTEN in Squamous Cell Carcinoma in Dogs
por: Monteiro, Alexandra, et al.
Publicado: (2023)

Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer
por: Shaheen, Sameerah, et al.
Publicado: (2016)

Overexpression of CTEN is associated with gefitinib resistance in non-small cell lung cancer
por: Lu, Xiangdong, et al.
Publicado: (2021)

Overexpression of CTEN relates to tumor malignant potential and poor outcomes of adenocarcinoma of the esophagogastric junction
por: Aratani, Kenichi, et al.
Publicado: (2017)

Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment
por: AlMusawi, Shaikha, et al.
Publicado: (2021)

ΔNp63α Transcriptionally Regulates the Expression of CTEN That Is Associated with Prostate Cell Adhesion
por: Yang, Kuan, et al.
Publicado: (2016)

CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer
por: Fleming, Jason C., et al.
Publicado: (2020)

Semen Modulates the Expression of NGF, ABHD2, VCAN, and CTEN in the Reproductive Tract of Female Rabbits
por: Gardela, Jaume, et al.
Publicado: (2020)

Correction: Overexpression of CTEN relates to tumor malignant potential and poor outcomes of adenocarcinoma of the esophagogastric junction
por: Aratani, Kenichi, et al.
Publicado: (2019)

Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches
por: Onyido, Emenike K., et al.
Publicado: (2016)

Profile of benign breast diseases in western Saudi Arabia: An 8-year histopathological review of 603 cases
por: Albasri, Abdulkader M.
Publicado: (2014)

A histopathological analysis of lung cancers. An 11-year retrospective study from Al-Madinah Al-Munawwarah, Saudi Arabia
por: Albasri, Abdulkader M.
Publicado: (2019)

Nasopharyngeal carcinoma metastasis to the breast
por: Albasri, Abdulkader M.
Publicado: (2020)

Clinicopathological characteristics of young versus older patients with breast cancer: A retrospective comparative study from the Madinah region of Saudi Arabia
por: Albasri, Abdulkader M.
Publicado: (2021)

CTen: a web-based platform for identifying enriched cell types from heterogeneous microarray data
por: Shoemaker, Jason E, et al.
Publicado: (2012)

CTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells
por: Lu, Xiangdong, et al.
Publicado: (2018)

FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway
por: Almozyan, Sheema, et al.
Publicado: (2021)

Downregulation of C-Terminal Tensin-Like Protein (CTEN) Suppresses Prostate Cell Proliferation and Contributes to Acinar Morphogenesis
por: Wu, Wei-Ming, et al.
Publicado: (2018)

CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of β-Catenin in Breast Cancer
por: Lu, Xiangdong, et al.
Publicado: (2021)

C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice
por: Chiu, Chun-Lung, et al.
Publicado: (2022)

Pancreatic Tumorigenesis: Oncogenic KRAS and the Vulnerability of the Pancreas to Obesity
por: Luo, Yongde, et al.
Publicado: (2021)

Histopathological pattern of testicular diseases in western Saudi Arabia
por: Albasri, Abdulkader M., et al.
Publicado: (2018)

Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture
por: Lorenzi, Federica, et al.
Publicado: (2016)

Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS
por: Chang, Xiao Yan, et al.
Publicado: (2018)

Histopathological pattern of skin cancer in Western region of Saudi Arabia: An 11 years experience
por: Albasri, Abdulkader M., et al.
Publicado: (2018)

The histopathological pattern of benign and non-neoplastic skin diseases at King Fahad Hospital, Madinah, Saudi Arabia
por: Albasri, Abdulkader M., et al.
Publicado: (2019)

Clinicopathological and prognostic significance of androgen receptor overexpression in colorectal cancer: Experience from Al-Madinah Al-Munawarah, Saudi Arabia
por: Albasri, Abdulkader M., et al.
Publicado: (2019)

Pattern of cancers in adolescent and young adults.: A 15-year retrospective study at King Fahad Hospital, Al-Madinah Al-Munawwarah, Saudi Arabia
por: Albasri, Abdulkader M., et al.
Publicado: (2021)

Morphological alterations of cultured human colorectal matched tumour and healthy organoids
por: Kashfi, Seyed Mohammad Hossein, et al.
Publicado: (2018)

Autophagy Induced during Pancreatitis Promotes KRAS-Dependent Transformation in the Pancreas
por: Iovanna, Juan L.
Publicado: (2016)

KRAS K104 modification affects the KRAS(G12D)-GEF interaction and mediates cell growth and motility
por: Chen, Chih-Chieh, et al.
Publicado: (2020)

The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1
por: Liao, Yi-Chun, et al.
Publicado: (2007)

Histopathological features of breast cancer in Al-Madinah region of Saudi Arabia
por: Albasri, Abdulkader, et al.
Publicado: (2014)

FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15
por: Li, Ningning, et al.
Publicado: (2015)

KRAS mutation analysis in ductal carcinoma of the pancreas; prognostic implications in elderly patients
por: Oldani, Alberto, et al.
Publicado: (2013)

Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation()()
por: Drosos, Yiannis, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_46dpngds5uhevei9k0ud0p4kla