Resistance of a Rodent Malaria Parasite to a Thymidylate Synthase Inhibitor Induces an Apoptotic Parasite Death and Imposes a Huge Cost of Fitness

BACKGROUND: The greatest impediment to effective malaria control is drug resistance in Plasmodium falciparum, and thus understanding how resistance impacts on the parasite's fitness and pathogenicity may aid in malaria control strategy. METHODOLOGY/PRINCIPAL FINDINGS: To generate resistance, P....

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Detalles Bibliográficos
Autores principales: Muregi, Francis W., Ohta, Isao, Masato, Uchijima, Kino, Hideto, Ishih, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116895/
https://www.ncbi.nlm.nih.gov/pubmed/21698180
http://dx.doi.org/10.1371/journal.pone.0021251

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