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Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the anti-proliferative effect of TGF-β

The anti-proliferative activity of transforming growth factor-β (TGF-β) is essential for maintaining normal tissue homeostasis and is lost in many types of tumors. Gene responses that are central to the TGF-β cytostatic program include activation of the cyclin-dependent kinase inhibitors p15(Ink4B)...

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Detalles Bibliográficos
Autores principales: Trinh, Bon Quy, Barengo, Nicolas, Naora, Honami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116964/
https://www.ncbi.nlm.nih.gov/pubmed/21297662
http://dx.doi.org/10.1038/onc.2011.4