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CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE
The prefrontal cortex (PFC) is thought to modulate sensory signals in posterior cortices during top-down attention(1,2), yet little is known about the underlying neural circuitry. Experimental and clinical evidence suggest that prefrontal dopamine plays an important role in cognitive functions(3), a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117113/ https://www.ncbi.nlm.nih.gov/pubmed/21572439 http://dx.doi.org/10.1038/nature09995 |
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author | Noudoost, Behrad Moore, Tirin |
author_facet | Noudoost, Behrad Moore, Tirin |
author_sort | Noudoost, Behrad |
collection | PubMed |
description | The prefrontal cortex (PFC) is thought to modulate sensory signals in posterior cortices during top-down attention(1,2), yet little is known about the underlying neural circuitry. Experimental and clinical evidence suggest that prefrontal dopamine plays an important role in cognitive functions(3), acting predominantly through D1 receptors (D1Rs). Here we show that dopamine D1Rs mediate prefrontal control of signals within visual cortex. We pharmacologically altered D1R-mediated activity within the frontal eye field (FEF) of the PFC and measured its effects on the responses of neurons within visual cortex. This manipulation was sufficient to enhance the response magnitude, orientation selectivity and response reliability of neurons in area V4 to an extent comparable with the known effects of top-down attention. The observed enhancement in V4 signals was restricted to neurons with response fields (RFs) overlapping the part of visual space affected by the D1R manipulation. Altering D1R or D2R-mediated FEF activity increased saccadic target selection, but the D2R manipulation did not enhance V4 signals. Our results identify a role of D1Rs in mediating the control of visual cortical signals by the PFC and demonstrate how processing within sensory areas can be altered in mental disorders involving prefrontal dopamine. |
format | Online Article Text |
id | pubmed-3117113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
record_format | MEDLINE/PubMed |
spelling | pubmed-31171132011-12-16 CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE Noudoost, Behrad Moore, Tirin Nature Article The prefrontal cortex (PFC) is thought to modulate sensory signals in posterior cortices during top-down attention(1,2), yet little is known about the underlying neural circuitry. Experimental and clinical evidence suggest that prefrontal dopamine plays an important role in cognitive functions(3), acting predominantly through D1 receptors (D1Rs). Here we show that dopamine D1Rs mediate prefrontal control of signals within visual cortex. We pharmacologically altered D1R-mediated activity within the frontal eye field (FEF) of the PFC and measured its effects on the responses of neurons within visual cortex. This manipulation was sufficient to enhance the response magnitude, orientation selectivity and response reliability of neurons in area V4 to an extent comparable with the known effects of top-down attention. The observed enhancement in V4 signals was restricted to neurons with response fields (RFs) overlapping the part of visual space affected by the D1R manipulation. Altering D1R or D2R-mediated FEF activity increased saccadic target selection, but the D2R manipulation did not enhance V4 signals. Our results identify a role of D1Rs in mediating the control of visual cortical signals by the PFC and demonstrate how processing within sensory areas can be altered in mental disorders involving prefrontal dopamine. 2011-05-15 /pmc/articles/PMC3117113/ /pubmed/21572439 http://dx.doi.org/10.1038/nature09995 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Noudoost, Behrad Moore, Tirin CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE |
title | CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE |
title_full | CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE |
title_fullStr | CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE |
title_full_unstemmed | CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE |
title_short | CONTROL OF VISUAL CORTICAL SIGNALS BY PREFRONTAL DOPAMINE |
title_sort | control of visual cortical signals by prefrontal dopamine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117113/ https://www.ncbi.nlm.nih.gov/pubmed/21572439 http://dx.doi.org/10.1038/nature09995 |
work_keys_str_mv | AT noudoostbehrad controlofvisualcorticalsignalsbyprefrontaldopamine AT mooretirin controlofvisualcorticalsignalsbyprefrontaldopamine |