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Merotelic kinetochore attachment: causes and effects

Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction...

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Detalles Bibliográficos
Autores principales: Gregan, Juraj, Polakova, Silvia, Zhang, Lijuan, Tolić-Nørrelykke, Iva M., Cimini, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117139/
https://www.ncbi.nlm.nih.gov/pubmed/21306900
http://dx.doi.org/10.1016/j.tcb.2011.01.003
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author Gregan, Juraj
Polakova, Silvia
Zhang, Lijuan
Tolić-Nørrelykke, Iva M.
Cimini, Daniela
author_facet Gregan, Juraj
Polakova, Silvia
Zhang, Lijuan
Tolić-Nørrelykke, Iva M.
Cimini, Daniela
author_sort Gregan, Juraj
collection PubMed
description Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merotelically attached kinetochores can persist until anaphase, causing chromatids to lag on the mitotic spindle and hindering their timely segregation. Recent studies showing that merotelic kinetochore attachment represents a major mechanism of aneuploidy in mitotic cells and is the primary mechanism of chromosomal instability in cancer cells have underlined the importance of studying merotely. Here, we highlight recent progress in our understanding of how cells prevent and correct merotelic kinetochore attachments.
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spelling pubmed-31171392011-07-19 Merotelic kinetochore attachment: causes and effects Gregan, Juraj Polakova, Silvia Zhang, Lijuan Tolić-Nørrelykke, Iva M. Cimini, Daniela Trends Cell Biol Review Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merotelically attached kinetochores can persist until anaphase, causing chromatids to lag on the mitotic spindle and hindering their timely segregation. Recent studies showing that merotelic kinetochore attachment represents a major mechanism of aneuploidy in mitotic cells and is the primary mechanism of chromosomal instability in cancer cells have underlined the importance of studying merotely. Here, we highlight recent progress in our understanding of how cells prevent and correct merotelic kinetochore attachments. Elsevier Science Publishers 2011-06 /pmc/articles/PMC3117139/ /pubmed/21306900 http://dx.doi.org/10.1016/j.tcb.2011.01.003 Text en © 2011 Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Review
Gregan, Juraj
Polakova, Silvia
Zhang, Lijuan
Tolić-Nørrelykke, Iva M.
Cimini, Daniela
Merotelic kinetochore attachment: causes and effects
title Merotelic kinetochore attachment: causes and effects
title_full Merotelic kinetochore attachment: causes and effects
title_fullStr Merotelic kinetochore attachment: causes and effects
title_full_unstemmed Merotelic kinetochore attachment: causes and effects
title_short Merotelic kinetochore attachment: causes and effects
title_sort merotelic kinetochore attachment: causes and effects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117139/
https://www.ncbi.nlm.nih.gov/pubmed/21306900
http://dx.doi.org/10.1016/j.tcb.2011.01.003
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