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Merotelic kinetochore attachment: causes and effects
Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Publishers
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117139/ https://www.ncbi.nlm.nih.gov/pubmed/21306900 http://dx.doi.org/10.1016/j.tcb.2011.01.003 |
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author | Gregan, Juraj Polakova, Silvia Zhang, Lijuan Tolić-Nørrelykke, Iva M. Cimini, Daniela |
author_facet | Gregan, Juraj Polakova, Silvia Zhang, Lijuan Tolić-Nørrelykke, Iva M. Cimini, Daniela |
author_sort | Gregan, Juraj |
collection | PubMed |
description | Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merotelically attached kinetochores can persist until anaphase, causing chromatids to lag on the mitotic spindle and hindering their timely segregation. Recent studies showing that merotelic kinetochore attachment represents a major mechanism of aneuploidy in mitotic cells and is the primary mechanism of chromosomal instability in cancer cells have underlined the importance of studying merotely. Here, we highlight recent progress in our understanding of how cells prevent and correct merotelic kinetochore attachments. |
format | Online Article Text |
id | pubmed-3117139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Elsevier Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-31171392011-07-19 Merotelic kinetochore attachment: causes and effects Gregan, Juraj Polakova, Silvia Zhang, Lijuan Tolić-Nørrelykke, Iva M. Cimini, Daniela Trends Cell Biol Review Accurate chromosome segregation depends on the proper attachment of sister kinetochores to microtubules emanating from opposite spindle poles. Merotelic kinetochore orientation is an error in which a single kinetochore is attached to microtubules emanating from both spindle poles. Despite correction mechanisms, merotelically attached kinetochores can persist until anaphase, causing chromatids to lag on the mitotic spindle and hindering their timely segregation. Recent studies showing that merotelic kinetochore attachment represents a major mechanism of aneuploidy in mitotic cells and is the primary mechanism of chromosomal instability in cancer cells have underlined the importance of studying merotely. Here, we highlight recent progress in our understanding of how cells prevent and correct merotelic kinetochore attachments. Elsevier Science Publishers 2011-06 /pmc/articles/PMC3117139/ /pubmed/21306900 http://dx.doi.org/10.1016/j.tcb.2011.01.003 Text en © 2011 Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license |
spellingShingle | Review Gregan, Juraj Polakova, Silvia Zhang, Lijuan Tolić-Nørrelykke, Iva M. Cimini, Daniela Merotelic kinetochore attachment: causes and effects |
title | Merotelic kinetochore attachment: causes and effects |
title_full | Merotelic kinetochore attachment: causes and effects |
title_fullStr | Merotelic kinetochore attachment: causes and effects |
title_full_unstemmed | Merotelic kinetochore attachment: causes and effects |
title_short | Merotelic kinetochore attachment: causes and effects |
title_sort | merotelic kinetochore attachment: causes and effects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117139/ https://www.ncbi.nlm.nih.gov/pubmed/21306900 http://dx.doi.org/10.1016/j.tcb.2011.01.003 |
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